Reproductive outcomes of single frozen-thawed embryo transfer in patients with endometriosis after preimplantation genetic testing

Huiling Qu, Hong Lv, Yan Kang, Lei Yan, Yanbo Du
Journal of assisted reproduction and genetics · 2023 · vol. 41(2) , pp. 429–435 · doi:10.1007/s10815-023-02996-5 · PMID:38079077 · PMC10894775 · W4389574470
article OA: green CC0 ⤵ 4 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study compared reproductive outcomes after euploid blastocyst transfer between infertile patients with and without endometriosis, finding no differences in pregnancy rates but a higher aneuploidy rate in the endometriosis group.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This retrospective cohort study evaluated reproductive outcomes in infertile patients with endometriosis who underwent preimplantation genetic testing (PGT) before embryo implantation, comparing them with matched controls using 1:3 propensity score matching. Across 625 PGT-tested patients, the authors measured live birth, clinical pregnancy, biochemical pregnancy, clinical abortion, premature birth, and aneuploid rates after single frozen-thawed euploid blastocyst transfer. They found no significant differences between endometriosis and control groups in live birth or pregnancy and adverse outcome rates, but blastocysts from the endometriosis group had a higher aneuploidy rate (P = 0.012). A key limitation is that the study is retrospective and reports on outcomes after PGT/transfer, with potential residual confounding despite matching. This paper is centrally about endometriosis — assessing whether endometriosis affects outcomes after single frozen-thawed embryo transfer following PGT.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

PURPOSE: The reproductive outcomes of patients with endometriosis who are infertile have attracted recent attention. We aimed to explore whether endometriosis affects endometrial receptivity by observing pregnancy outcomes following a euploid blastocyst frozen embryo transfer. METHODS: This retrospective cohort study analyzed the data of patients with endometriosis from the reproductive hospital affiliated to Shandong University between January 2015 and December 2021. Control groups were matched using the 1:3 propensity score. The live birth, clinical pregnancy, biochemical pregnancy, clinical abortion, premature birth, and aneuploid rates were compared between the control group and endometriosis group. RESULTS: A total of 625 patients who underwent preimplantation genetic testing (PGT) prior to embryo implantation were included in the analysis. There were no significant differences in the live birth, clinical pregnancy, biochemical pregnancy, clinical abortion, and premature birth rates between the two groups. The aneuploidy rate of blastocysts obtained from the endometriosis group was higher than that of the control group (P = 0.012). CONCLUSION: Pregnancy outcomes using frozen embryos after PGT in patients with endometriosis did not differ from those in other women experiencing infertility. However, endometriosis may affect the quality of oocytes, resulting in a higher rate of aneuploidy.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (4)

Source provenance

europepmc
last seen: 2026-06-20T06:14:18.781669+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-06-20T06:12:46.583045+00:00
License: CC0 · commercial use OK