{"paper_id":"edbae4c5-219c-420c-bce2-397e621ccf45","body_text":"Abstract\nPurpose\nThe reproductive outcomes of patients with endometriosis who are infertile have attracted recent attention. We aimed to explore whether endometriosis affects endometrial receptivity by observing pregnancy outcomes following a euploid blastocyst frozen embryo transfer.\nMethods\nThis retrospective cohort study analyzed the data of patients with endometriosis from the reproductive hospital affiliated to Shandong University between January 2015 and December 2021. Control groups were matched using the 1:3 propensity score. The live birth, clinical pregnancy, biochemical pregnancy, clinical abortion, premature birth, and aneuploid rates were compared between the control group and endometriosis group.\nResults\nA total of 625 patients who underwent preimplantation genetic testing (PGT) prior to embryo implantation were included in the analysis. There were no significant differences in the live birth, clinical pregnancy, biochemical pregnancy, clinical abortion, and premature birth rates between the two groups. The aneuploidy rate of blastocysts obtained from the endometriosis group was higher than that of the control group (P = 0.012).\nConclusion\nPregnancy outcomes using frozen embryos after PGT in patients with endometriosis did not differ from those in other women experiencing infertility. However, endometriosis may affect the quality of oocytes, resulting in a higher rate of aneuploidy.\nSimilar content being viewed by others\nData availability\nThe data underlying this article are available from the corresponding author on reasonable request.\nReferences\nMacer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. 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Fertil Steril. 2009;92(5):1749–52. https://doi.org/10.1016/j.fertnstert.2009.05.006.\nAcknowledgements\nWe thank all authors for the help in performing the study.\nFunding\nThis study was supported by the National Key Research and Development Program of China (2022YFC2704002) and the National Natural Science Foundation of China (81571414) and the Natural Science Youth Foundation of Shandong Province (ZR2020QH058).\nAuthor information\nAuthors and Affiliations\nContributions\nHQ, YD, and LY conceived and designed the study. HL and YK provided clinical knowledge and guidance in paper writing. HQ and LY analyzed the data and wrote the manuscript. LY and YD modify the paper. All authors read and approved the final manuscript.\nCorresponding authors\nEthics declarations\nEthics approval\nThe study has been approved by the Institutional Review Board (IRB) of the Reproductive Hospital affiliated to Shandong University (2020–14).\nConflict of interest\nThe authors declare no competing interests.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nQu, H., Lv, H., Kang, Y. et al. Reproductive outcomes of single frozen-thawed embryo transfer in patients with endometriosis after preimplantation genetic testing. J Assist Reprod Genet 41, 429–435 (2024). https://doi.org/10.1007/s10815-023-02996-5\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s10815-023-02996-5","source_license":"CC0","license_restricted":false}