Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis.

Abdülkadir Turgut, A Turgut, Ali Özler, A Özler, N Y Görük, Görük Ny, S Y Tunc, Tunc Sy, O Evliyaoglu, Osman Evliyaoğlu, Gül T, T Gül
European review for medical and pharmacological sciences · 2013 · vol. 17(11) , pp. 1472–8 · PMID:23771536 · W2470889613
article OA: closed CC0 ⤵ 38 in-corpus citations
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This study found that women with advanced-stage endometriosis had higher serum copper, ceruloplasmin, and oxidative stress markers compared to controls.

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Abstract

AIM: To compare patients with advanced stage endometriosis with control patients without endometriosis with respect to serum Copper (Cu) and Ceruloplasmin (Cp) levels and oxidative stress markers in order to evaluate the importance of these parameters in the pathogenesis of endometriosis. PATIENTS AND METHODS: A total of 72 women who underwent laparoscopy or laparotomy for evaluation of infertility, pelvic pain, pelvic mass, tubal ligation or endometriosis were enrolled for this prospective clinical study. Patients were divided into two groups by visual diagnosis at surgery and histological confirmation of endometriosis: control patients (n=41) without endometriosis and study group (n=31) with stage III/IV (advanced stage) endometriosis. Serum Cu, Cp, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), malondialdehyde (MDA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were compared between the two groups. Correlations between Cu, Cp and oxidative stress markers were determined. RESULTS: Serum TOS, OSI, Cu, Cp, TG, TC, LDL were significantly higher, whereas TAS, PON-1 activity and HDL were significantly lower, in women with advanced-stage endometriosis than in control groups. There was no difference in serum MDA activities between the two groups. Positive correlations were found between Cu and TOS, Cu and OSI, Cu and Cp, while a negative correlation was found between Cu and PON-1 in the advanced-stage endometriosis group. Positive correlations were found between Cp and TOS, and Cp and OSI in the advanced-stage endometriosis group. CONCLUSIONS: Cu and Cp appear to be associated with the etiopathogenesis of and oxidative stress in endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Ceruloplasmin Copper Endometriosis Oxidative Stress Adult Case-Control Studies Ceruloplasmin Copper Endometriosis Female Humans Lipoproteins, HDL Lipoproteins, HDL Lipoproteins, LDL Lipoproteins, LDL Prospective Studies

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Cited by (38)

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