Oxidative Stress in Endometrial Flushing Fluid of Patients with Polycystic Ovary Syndrome, Endometrioma and Uterine Leiomyoma: Comparison with Healthy Controls

Mustafa Demir, Onur İnce, Bülent Yılmaz, Mert Ulaş Barut, Ulviye Cansu ÖZTÜRK, Avni Kılıc, Ahmet Berkız Turp, Recep Sütçü, Seyithan Tayşi
In: Gynecology Obstetrics & Reproductive Medicine · 2020 · vol. 26(2) , pp. 123–129 · doi:10.21613/gorm.2020.1091 · W3036619712
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study compared oxidative stress markers in endometrial fluid from women with PCOS, uterine leiomyoma, endometrioma, and healthy controls, finding no significant differences among groups.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This cross-sectional study compared oxidative-stress–related biomarkers in endometrial flushing fluid collected during the implantation window from women with polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19), and healthy controls (n=20), focusing on total antioxidant status, ceruloplasmin, total sulfhydryl, total oxidant status, lipid hydroperoxide, and an oxidative stress index. The authors report that antioxidant markers and oxidant-related markers did not differ significantly across the four groups, including total antioxidant status, ceruloplasmin, total sulfhydryl, total oxidant status, lipid hydroperoxide, and oxidative stress index. A major caveat is that the study design and sample sizes limit conclusions about oxidative stress differences and cannot establish causality. This paper is centrally about endometriosis — specifically, it includes endometrioma patients and compares implantation-window endometrial flushing fluid oxidative stress biomarkers against controls.

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Abstract

OBJECTIVE: Polycystic ovary syndrome, myoma uteri and endometrioma are frequently seen gynecologic problems and all three diseases may cause infertility. Aim of this cross-sectional study was to compare total antioxidant status, ceruloplasmin, total sulfhydryl , total oxidant status, lipid hydroperoxide and oxidative stress index levels in endometrial flushing fluid of patients with Polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19), and healthy women (n=20).STUDY DESIGN: We compare endometrial flushing fluid of patients with polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19) and healthy women (n=20). Endometrial flushing fluid samples were collected during the implantation window of all women.RESULTS: Mean age of groups was 28.90±5.45, 37.25±2.73, 32.84±6.62 and 32.15±5.18 in Polycystic ovary syndrome, myoma uteri, endometrioma and control groups, respectively (p<0.05). Mean total antioxidant status, ceruloplasmin and total sulfhydryl levels indicating antioxidant state were comparable between Polycystic ovary syndrome, myoma uteri, endometrioma and control groups (p=0.806, p=0.156, p=0.328 respectively for markers). Similarly, oxidant state-related markers didn’t differ significantly between 4 groups (p=0.090 for total oxidant status, p=0.087 for lipid hydroperoxide, p=0.312 for oxidative stress index).CONCLUSION: Endometrial flushing fluid total antioxidant status, total oxidant status, lipid hydroperoxide, ceruloplasmin, and total sulfhydryl levels during implantation window didn’t differ between women with Polycystic ovary syndrome, uterine leiomyoma, endometrioma, and healthy controls.
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Objective

Polycystic ovary syndrome, myoma uteri and endometrioma are frequently seen gynecologic problems and all three diseases may cause infertility. Aim of this cross-sectional study was to compare total antioxidant status, ceruloplasmin, total sulfhydryl , total oxidant status, lipid hydroperoxide and oxidative stress index levels in endometrial flushing fluid of patients with Polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19), and healthy women (n=20). STUDY DESIGN: We compare endometrial flushing fluid of patients with polycystic ovary syndrome (n=20), uterine leiomyoma (n=20), endometrioma (n=19) and healthy women (n=20). Endometrial flushing fluid samples were collected during the implantation window of all women.

Results

Mean age of groups was 28.90±5.45, 37.25±2.73, 32.84±6.62 and 32.15±5.18 in Polycystic ovary syndrome, myoma uteri, endometrioma and control groups, respectively (p<0.05). Mean total antioxidant status, ceruloplasmin and total sulfhydryl levels indicating antioxidant state were comparable between Polycystic ovary syndrome, myoma uteri, endometrioma and control groups (p=0.806, p=0.156, p=0.328 respectively for markers). Similarly, oxidant state-related markers didn’t differ significantly between 4 groups (p=0.090 for total oxidant status, p=0.087 for lipid hydroperoxide, p=0.312 for oxidative stress index).

Conclusion

Endometrial flushing fluid total antioxidant status, total oxidant status, lipid hydroperoxide, ceruloplasmin, and total sulfhydryl levels during implantation window didn’t differ between women with Polycystic ovary syndrome, uterine leiomyoma, endometrioma, and healthy controls. Downloads Downloads Published How to Cite Issue Section License All the articles published in GORM are licensed with "Creative Commons Attribution 4.0 License (CC BY 4.0)". This license entitles all parties to copy, share and redistribute all the articles, data sets, figures and supplementary files published in this journal in data mining, search engines, web sites, blogs and other digital platforms under the condition of providing references.

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