Endometriosis, Psoriasis, and Psoriatic Arthritis: A Prospective Cohort Study

Holly R Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Pina Carvalho, Luiz Fernando Carvalho, Abrar A Qureshi, Mauricio Abrao, Maurício Simões Abrão, Stacey A Missmer
American journal of epidemiology · 2022 · vol. 191(6) , pp. 1050–1060 · doi:10.1093/aje/kwac009 · PMID:35029650 · PMC9393059 · W4206516229
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Psoriasis with concomitant psoriatic arthritis showed a doubled risk of endometriosis, while endometriosis was not associated with subsequent psoriasis or psoriatic arthritis risk.

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Abstract

Endometriosis, psoriasis, and psoriatic arthritis (PsA) are chronic inflammatory disorders whose etiologies remain poorly understood but may be correlated, as endometriosis has been associated with other inflammatory disorders. We investigated the bidirectional associations between laparoscopically confirmed endometriosis and physician-diagnosed psoriasis and PsA in the Nurses' Health Study II cohort (n = 116,429, United States, 1991-2013). We confirmed 4,112 incident cases of laparoscopically confirmed endometriosis (mean age at diagnosis = 40.3 years) and 697 validated physician-diagnosed cases of psoriasis (mean age at diagnosis = 43.6 years), 110 of which presented with concomitant PsA. A history of psoriasis with concomitant PsA was associated with a 2-fold higher risk of endometriosis (hazard ratio (HR) = 2.01, 95% CI: 1.23, 3.30); however, no association was observed between psoriasis without PsA and endometriosis risk (HR = 0.93, 95% CI: 0.68, 1.26). When endometriosis was the exposure, it was not associated with a risk of subsequent psoriasis (HR = 1.28, 95% CI: 0.95, 1.72). The risk of psoriasis with PsA was notably higher; however, the sample size was small and the confidence intervals wide (HR = 1.77, 95% CI: 0.89, 3.52). Our findings suggest that psoriasis with concomitant PsA is associated with greater risk of laparoscopically confirmed endometriosis. In addition, there was a suggestive association between endometriosis diagnosis and subsequent risk of psoriasis with PsA.

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Condition tags

endometriosis

MeSH descriptors

Arthritis, Psoriatic Arthritis, Psoriatic Arthritis, Psoriatic Endometriosis Endometriosis Endometriosis Psoriasis Psoriasis Psoriasis Cohort Studies Female Humans Prospective Studies Risk Factors United States United States

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