Increased levels of oxidative stress markers in the peritoneal fluid of women with endometriosis

Polak G, Grzegorz Polak, Iwona Wertel, Bartłomiej Barczyński, Barczyński B, Wojciech Kwaśniewski, Wiesława Bednarek, Bednarek W, Kotarski J, Jan Kotarski
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 168(2) , pp. 187–190 · doi:10.1016/j.ejogrb.2012.12.043 · PMID:23351670 · W2026637076
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This study found elevated levels of oxidative stress markers in the peritoneal fluid of women diagnosed with endometriosis compared to healthy controls.

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Abstract

ObjectiveTo evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-isoprostane levels in the peritoneal fluid (PF) of women with endometriosis.Study designOne hundred and ten women with laparoscopically and histopathologically confirmed endometriosis and, as reference groups, 119 patients with simple serous (n=78) and dermoid (n=41) ovarian cysts were studied. Peritoneal fluid 8-OHdG and 8-isoprostane concentrations were evaluated by enzyme-linked immunosorbent assays.Results8-OHdG and 8-isoprostane levels in peritoneal fluid were significantly higher in patients with endometriosis compared with the reference groups. Higher PF 8-OHdG and 8-isoprostane concentrations were observed in patients with advanced stages of endometriosis. A statistically significant positive correlation was found between 8-OHdG and 8-isoprostane levels in peritoneal fluid.ConclusionEndometriosis induces greater oxidative stress and frequent DNA mutations in peritoneal fluid than nonendometriotic ovarian cysts. The most severe oxidative stress occurs in the peritoneal cavity of women with more advanced stages of the disease.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Deoxyguanosine Dinoprost Endometriosis Ovarian Cysts Oxidative Stress Up-Regulation 8-Hydroxy-2'-Deoxyguanosine Adolescent Adult Ascitic Fluid Biomarkers Biomarkers Cysts Cysts Cysts Cysts Cysts Deoxyguanosine Deoxyguanosine

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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