Exploring Oxidative Stress in Different Endometriosis Phenoptypes: Insights from Ovarian and Systemic Perspectives by the Study of SIRT3

Anna Goday, Laura Valls-Roca, Laura Valls‐Roca, Marta Méndez, Yolanda Cívico, Meritxell Gràcia, Mariona Guitart‐Mampel, Mariona Guitart-Mampel, Gemma Casals, Sara Peralta, Aina Borrás, Francisco Fábregues, Francisco Fàbregues, Inés Agustí, Yasmina Barral, Cristina Ros, Maria Àngels Martínez, M.C. Martínez, Mariona Rius, Salvadora Cívico, Salvadora Cı́vico, Glòria Garrabou, Francisco Carmona, Dolors Manau
International journal of molecular sciences · 2025 · vol. 26(18) , pp. 9110 · doi:10.3390/ijms26189110 · PMID:41009667 · W4414329567
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This longitudinal study found higher SIRT3 levels in patients with deep endometriosis and those with prior surgeries, suggesting SIRT3 may be linked to disease severity and a potential therapeutic target.

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Abstract

Endometriosis affects about 10% of reproductive-aged women, characterized by endometrial-like tissue outside the uterus, leading to chronic inflammation. The exact cause remains unknown, though genetic and epigenetic factors are increasingly recognized alongside traditional theories. The disease manifests in forms such as endometriomas, whether superficial or peritoneal, and deep infiltrating lesions, often causing chronic pain and infertility. Infertility affects nearly 50% of patients, requiring expensive treatments like in vitro fertilization. Oxidative stress plays a key role in endometriosis, with sirtuins, especially SIRT3, emerging as important regulators. SIRT3, located in mitochondria, helps manage oxidative stress and redox balance. Despite extensive research, no diagnostic biomarkers exist. This longitudinal study compares oxidative stress markers and SIRT3 levels in patients with different endometriosis types. While classic oxidative stress markers showed no significant differences, higher SIRT3 levels were observed in peripheral blood mononuclear cells of patients with deep endometriosis. Additionally, patients with prior surgeries had elevated SIRT3 levels, indicating a possible link between disease severity and SIRT3 expression. The findings suggest SIRT3 as a potential therapeutic target in endometriosis management.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Ovary Ovary Ovary Ovary Ovary Ovary Ovary Ovary Ovary

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

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