Levels of total antioxidant capacity and 8-hydroxy-2′-deoxyguanosine of serum and follicular fluid in women undergoing in vitro fertilization: focusing on endometriosis

Ákos Várnagy, Várnagy Á, Tamás Kőszegi, Erzséber Györgyi, Györgyi E, Sarolta Szegedi, Szegedi S, Sulyok E, Endre Sulyok, Viktória Prémusz, Bódis J, József Bódis
Human fertility (Cambridge, England) · 2018 · vol. 23(3) , pp. 200–208 · doi:10.1080/14647273.2018.1535719 · PMID:30422732 · W2901270268
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This study measured serum and follicular fluid antioxidant capacity and 8-hydroxy-2′-deoxyguanosine in women undergoing IVF, finding they responded differently to ovarian stimulation and negatively impacted embryo quality.

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Abstract

fertilization (IVF). The impact of these biomarkers on IVF outcome was also analysed. Samples were obtained from 61 patients (age: 36.40 ± 4.99 years; BMI: 22.54 ± 2.46; infertility: 3.7 ± 2.5 years [mean ± SD]) before and after controlled ovarian hyperstimulation (COH). Patients with and without endometriosis were also evaluated separately. TAC was quantified by enhanced chemiluminescence assay and 8-OHdG was measured by enzyme-linked immunosorbent assay. It was demonstrated that these biomarkers responded to COH differently. No relationship could be detected in their FF levels, although their cumulative serum levels were inversely related. Both FF TAC and FF 8-OHdG had a negative impact on the number of good quality embryos, but an effect of Serum TAC and 8-OHdG could not be observed. When women with and without endometriosis were evaluated separately, inconsistent results were obtained. However, women without endometriosis had higher levels of serum and FF TAC when they progressed to clinical pregnancy. Our findings support the notion that OS has an important contribution to the reproductive potential in IVF patients, the ideal biomarkers of outcome measures, however, need to be further explored.

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Condition tags

endometriosisinfertility

MeSH descriptors

8-Hydroxy-2'-Deoxyguanosine 8-Hydroxy-2'-Deoxyguanosine Antioxidants Endometriosis Follicular Fluid 8-Hydroxy-2'-Deoxyguanosine Adult Antioxidants Biomarkers Endometriosis Female Fertilization in Vitro Follicular Fluid Humans Oxidative Stress

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