Antimüllerian Hormone and Oxidative Stress Biomarkers as Predictors of Successful Pregnancy in Polycystic Ovary Syndrome, Endometriosis and Tubal Infertility Factor

Teja Fabjan, Eda Vrtačnik-Bokal, Eda VrtaÄŤnik-Bokal, Irma Virant‐Klun, Irma Virant-Klun, Jure Bedenk, Kristina Kumer, Joško Osredkar, Joško Osredkar
Acta chimica Slovenica · 2020 · vol. 67(3) , pp. 885–895 · doi:10.17344/acsi.2020.5864 · PMID:33533416 · W3023867056
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study measured oxidative stress and AMH in follicular fluid from women with PCOS, endometriosis, or tubal infertility, finding 8-OHdG in PCOS patients predicted oocyte maturation and fertilization success.

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This prospective study measured oxidative stress markers in follicular fluid and evaluated whether they could predict successful embryo development in women with polycystic ovary syndrome (PCOS), endometriosis, and tubal infertility factor (TIF), compared with healthy controls with male-factor infertility. From dominant follicles, the authors quantified total antioxidant status (TAS), 8-isoprostane (8-IP), 8-hydroxy-2’-deoxyguanosine (8-OHdG), and anti-Müllerian hormone (AMH), and reported that oxidative stress marker levels differed by diagnosis, including lower 8-IP and TAS in endometriosis and generally lower markers in TIF with exceptions for 8-OHdG and AMH. They found that the follicular-fluid 8-OHdG level in PCOS patients was a good predictive marker for matured and fertilized oocytes, while other associations were not highlighted as predictive. The paper does not state sample size or other methodological caveats in the provided text and concludes that further research is needed for IVF application. Relevance to endometriosis: endometriosis patients were prospectively enrolled and showed lower follicular-fluid 8-IP and TAS, though the main predictive result emphasized PCOS rather than endometriosis.

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Abstract

Oxidative stress in the follicular fluid (FF) is thought to be responsible for the abnormal development of oocytes. In our study patients with polycystic ovarian syndrome (PCOS), endometriosis, and tubal infertility factor (TIF), and healthy women with a male factor of infertility, were prospectively enrolled. From each patient, a sample of individual FF was collected from a dominant follicle. Concentration levels of TAS, 8-IP, 8-OHdG, and AMH were determined. In women with PCOS, we found significantly lower values of oxidative stress markers in the FF. 8-IP and TAS levels were lower in the FF of women with endometriosis. In women with TIF, we also found significantly lower values of all tested markers in the FF, except for 8-OHdG and AMH. We wanted to see whether the biomarker measured in the FF in an individual diagnosis could predict a successfully obtained embryo from this particular follicle. The FF 8-OHdG result in PCOS patients stood out and proved to be a good predictive marker of matured and fertilized oocytes in these patients. Further research is needed to be able to apply the acquired knowledge in improving the outcome of IVF procedures.
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Antimüllerian Hormone and Oxidative Stress Biomarkers as Predictors of Successful Preg-nancy in Polycystic Ovary Syndrome, Endometriosis and Tubal Infertility Factor DOI: https://doi.org/10.17344/acsi.2020.5864Keywords: Oxidative stress, Antimüllerian hormone, Polycystic ovary syndrome, Endometriosis, Tubal infertility factor, InfertilityAbstract Oxidative stress in the follicular fluid (FF) is thought to be responsible for the abnormal development of oocytes. In our study patients with polycystic ovarian syndrome (PCOS), endometriosis, and tubal infertility factor (TIF), and healthy women with a male factor of infertility, were prospectively enrolled. From each patient, a sample of individual FF was collected from a dominant follicle. Concentration levels of TAS, 8-IP, 8-OHdG, and AMH were determined. In women with PCOS, we found significantly lower values of oxidative stress markers in the FF. 8-IP and TAS levels were lower in the FF of women with endometriosis. In women with TIF, we also found significantly lower values of all tested markers in the FF, except for 8-OHdG and AMH. We wanted to see whether the biomarker measured in the FF in an individual diagnosis could predict a successfully obtained embryo from this particular follicle. The FF 8-OHdG result in PCOS patients stood out and proved to be a good predictive marker of matured and fertilized oocytes in these patients. Further research is needed to be able to apply the acquired knowledge in improving the outcome of IVF procedures. Downloads Published Issue Section License Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License

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Condition tags

endometriosisinfertility

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Infertility, Female Live Birth Oxidative Stress Polycystic Ovary Syndrome 8-Hydroxy-2'-Deoxyguanosine 8-Hydroxy-2'-Deoxyguanosine Adult Anti-Mullerian Hormone Biomarkers Biomarkers Dinoprost Dinoprost Dinoprost Endometriosis Endometriosis Female Follicular Fluid Follicular Fluid

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