Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF

Nalini Santanam, Nathaniel Zoneraich, Sampath Parthasarathy
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 24(4) , pp. 619–626 · doi:10.1177/1933719116667225 · PMID:27662901 · PMC5933202 · W2521428060
article OA: green CC0 ⤵ 20 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study found significantly higher myeloperoxidase concentrations in follicular fluid of women with moderate/severe endometriosis undergoing IVF, which decreased with antioxidant supplementation and trended with poorer reproductive outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This case-control prospective study measured plasma and follicular fluid myeloperoxidase (MPO) concentrations, an oxidative stress marker, in 68 women with and without endometriosis undergoing IVF, alongside estradiol levels and IVF outcomes (oocyte quality, fertilization, implantation, and pregnancy). Follicular fluid MPO was higher in moderate/severe endometriosis than controls or mild endometriosis, and vitamin E and C supplementation significantly lowered follicular fluid MPO only in the moderate/severe group; plasma MPO did not differ between groups. The paper reports a trend toward reduced maturation, implantation, and clinical pregnancy rates with greater endometriosis severity and higher MPO levels, with an explicit caveat that the findings are trends rather than definitive outcome differences. This paper is centrally about endometriosis — it evaluates MPO as an oxidative stress target linked to IVF-associated infertility in women with endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertilization in Vitro Oocytes Peroxidase Adult Embryo Transfer Endometriosis Endometriosis Female Follicular Fluid Follicular Fluid Humans Oocytes Ovulation Induction Oxidative Stress Oxidative Stress Peroxidase Peroxidase Pregnancy Pregnancy Rate

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (57)

Cited by (20)

Source provenance

europepmc
last seen: 2026-06-16T06:07:01.518242+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:54.390225+00:00
License: CC0 · commercial use OK