Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF

Nalini Santanam, Nathaniel Zoneraich, Zoneraich N, Parthasarathy S, Sampath Parthasarathy
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 24(4) , pp. 619–626 · doi:10.1177/1933719116667225 · PMID:27662901 · PMC5933202 · W2521428060
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This study investigated myeloperoxidase (MPO) levels in women with endometriosis undergoing IVF, finding elevated MPO in follicular fluid correlating with disease severity and decreased IVF outcomes.

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This case-control prospective study measured plasma and follicular fluid myeloperoxidase (MPO) concentrations, an oxidative stress marker, in 68 women with and without endometriosis undergoing IVF, alongside estradiol levels and IVF outcomes (oocyte quality, fertilization, implantation, and pregnancy). Follicular fluid MPO was higher in moderate/severe endometriosis than controls or mild endometriosis, and vitamin E and C supplementation significantly lowered follicular fluid MPO only in the moderate/severe group; plasma MPO did not differ between groups. The paper reports a trend toward reduced maturation, implantation, and clinical pregnancy rates with greater endometriosis severity and higher MPO levels, with an explicit caveat that the findings are trends rather than definitive outcome differences. This paper is centrally about endometriosis — it evaluates MPO as an oxidative stress target linked to IVF-associated infertility in women with endometriosis.

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Abstract

As infertility is intimately associated with endometriosis, the levels of myeloperoxidase (MPO), a leukocyte enzyme and an oxidative stress marker, were determined in a case-control prospective study of 68 women with and without endometriosis undergoing in vitro fertilization in the outpatient fertility center within a tertiary care academic medical center. Measured values included plasma and follicular fluid (FF) concentrations of MPO, plasma estradiol, as well as oocyte quality, fertilization, implantation, and pregnancy rates in these women. In FF (mean ± standard error of mean [SEM]), the MPO concentrations (ng/mL) for controls were 4.3 ± 0.37, mild endometriosis (stages I-II) 3.9 ± 0.17, and moderate/severe endometriosis (stages III-IV) 16.6 ± 12.5 ( P < 0.0143). In FF, among patients supplemented with vitamins E and C, the MPO levels decreased significantly only in moderate/severe endometriosis from 25.3 ± 22.0 ng/mL to 4.9 ± 1.61 ng/mL, respectively. Plasma levels of MPO between groups did not change. Outcome data revealed a trend toward decreased percentage of mature oocytes, implantation rate, and clinical pregnancy rate with severity of endometriosis and MPO levels. Myeloperoxidase may be a potential oxidative stress target for endometriosis-associated infertility.
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Keywords

antioxidants; infertility; oxidative stress

Abstract

As infertility is intimately associated with endometriosis, the levels of myeloperoxidase (MPO), a leukocyte enzyme and an oxidative stress marker, were determined in a case-control prospective study of 68 women with and without endometriosis undergoing in vitro fertilization in the outpatient fertility center within a tertiary care academic medical center. Measured values included plasma and follicular fluid (FF) concentrations of MPO, plasma estradiol, as well as oocyte quality, fertilization, implantation, and pregnancy rates in these women. In FF (mean ± standard error of mean [SEM]), the MPO concentrations (ng/ mL) for controls were 4.3±0.37, mild endometriosis (stages I-II) 3.9±0.17, and moderate/severe endometriosis (stages III-IV) 16.6±12.5 (P < 0.0143). In FF, among patients supplemented with vitamins E and C, the MPO levels decreased significantly only in moderate/severe endometriosis from 25.3 ± 22.0 ng/mL to 4.9 ± 1.61 ng/mL, respectively. Plasma levels of MPO between groups did not change. Outcome data revealed a trend toward decreased percentage of mature oocytes, implantation rate, and clinical pregnancy rate with severity of endometriosis and MPO levels. Myeloperoxidase may be a potential oxidative stress target for endometriosis-associated infertility. Publication Date 4-1-2017 Publication Title Reproductive Sciences Volume 24 Issue 4 Number of Pages 619-626 Document Type Article Personal Identifier scopus DOI Link https://doi.org/10.1177/1933719116667225 Copyright Status Unknown Socpus ID 85018350823 (Scopus) Source API URL https://api.elsevier.com/content/abstract/scopus_id/85018350823 STARS Citation Santanam, Nalini; Zoneraich, Nathaniel; and Parthasarathy, Sampath, "Myeloperoxidase As A Potential Target In Women With Endometriosis Undergoing Ivf" (2017). Scopus Export 2015-2019. 6071. https://stars.library.ucf.edu/scopus2015/6071

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertilization in Vitro Oocytes Peroxidase Adult Embryo Transfer Endometriosis Endometriosis Female Follicular Fluid Follicular Fluid Humans Oocytes Ovulation Induction Oxidative Stress Oxidative Stress Peroxidase Peroxidase Pregnancy Pregnancy Rate

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