Identification of biomarkers for drug-resistant endometriosis using clinical proteomics

Yoichi Kobayashi; Toshiyuki Fukutomi; Shizuka Mita; Momoe Watanabe; Atsushi Suzuki

doi:10.1007/s13577-020-00465-0

Identification of biomarkers for drug-resistant endometriosis using clinical proteomics

Yoichi Kobayashi, Toshiyuki Fukutomi, Shizuka Mita, Momoe Watanabe, Atsushi Suzuki

Human cell · 2021 · vol. 34(2) , pp. 394–399 · doi:10.1007/s13577-020-00465-0 · PMID:33387360 · W3116991653

article OA: closed CC0 ⤵ 3 in-corpus citations

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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Proteomics identified proteins related to neutrophil activation and inflammation, including azurocidin, in drug-resistant endometriosis cases compared to sensitive ones.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper investigated the mechanisms underlying resistance to the progestin dienogest (DNG) in a subset of endometriotic cases by performing clinical proteomics comparing protein expression profiles in DNG-sensitive versus DNG-resistant endometriotic cyst fluid. Proteins associated with neutrophil/granulocyte activation (e.g., myeloperoxidase, lactotransferrin) and inflammatory processes (including azurocidin and neutrophil gelatinase-associated lipocalin) were identified as extracted candidate markers, with azurocidin highlighted as potentially important due to its protease activity related to insulin-like growth factor-1 signaling. A major limitation explicitly acknowledged in the text is that the authors mainly identify and propose biomarkers, calling for further investigation rather than establishing causal mechanisms. This paper is centrally about endometriosis — it identifies proteomic biomarkers linked to dienogest-resistant endometriotic cysts and implicates inflammation-related proteins (especially azurocidin) in resistance-related biology and possible carcinogenesis of endometrioma.

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Condition tags

endometriosis

MeSH descriptors

Antimicrobial Cationic Peptides Blood Proteins Drug Resistance Endometriosis Endometriosis Nandrolone Proteomics Antimicrobial Cationic Peptides Antimicrobial Cationic Peptides Antimicrobial Cationic Peptides Blood Proteins Blood Proteins Blood Proteins Carcinogenesis Carcinogenesis Cell Line Drug Resistance Endometriosis Endometriosis Endometriosis

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References (21)

Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress via openalex
Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex
Endometriotic cyst fluid induces reactive oxygen species (ROS) in human immortalized epithelial cells derived from ovarian endometrioma via openalex
ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8 via openalex
Is dienogest the best medical treatment for ovarian endometriomas? Results of a multicentric case control study via openalex
Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy via openalex
Matrix metalloproteinases are elevated in the urine of patients with endometriosis via openalex
Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF via openalex
Prevalence and Symptomatic Burden of Diagnosed Endometriosis in the United States: National Estimates from a Cross-Sectional Survey of 59,411 Women via openalex
Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity via openalex
W6612567677 via openalex
W1981024564 via openalex
W1986656413 via openalex
W2031608734 via openalex
W2043204396 via openalex
W2053943711 via openalex
W2080352379 via openalex
W2085904736 via openalex
W4211081176 via openalex
W1600271592 via openalex

Cited by (3)

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License: CC0 · commercial use OK

[1] Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress via openalex

[2] Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex

[3] Endometriotic cyst fluid induces reactive oxygen species (ROS) in human immortalized epithelial cells derived from ovarian endometrioma via openalex

[4] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[5] Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8 via openalex

[6] Is dienogest the best medical treatment for ovarian endometriomas? Results of a multicentric case control study via openalex

[7] Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy via openalex

[8] Matrix metalloproteinases are elevated in the urine of patients with endometriosis via openalex

[9] Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF via openalex

[10] Prevalence and Symptomatic Burden of Diagnosed Endometriosis in the United States: National Estimates from a Cross-Sectional Survey of 59,411 Women via openalex

[11] Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity via openalex

[12] W6612567677 via openalex

[13] W1981024564 via openalex

[14] W1986656413 via openalex

[15] W2031608734 via openalex

[16] W2043204396 via openalex

[17] W2053943711 via openalex

[18] W2080352379 via openalex

[19] W2085904736 via openalex

[20] W4211081176 via openalex

[21] W1600271592 via openalex