[Increased oxidized LDL cholesterol levels in peritoneal fluid of women with advanced-stage endometriosis].

Grzegorz Polak, Diana Mazurek, Ewelina Rogala, Aldona Nowicka, Magdalena Derewianka-Polak, Jan Kotarski
Ginekologia polska · 2011 · vol. 82(3) , pp. 191–4 · PMID:21735686 · W42495875
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This study found significantly increased levels of oxidized LDL cholesterol in the peritoneal fluid of women with advanced-stage endometriosis compared to controls.

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The study evaluated whether oxidized low-density lipoprotein (ox-LDL) is present in peritoneal fluid and whether levels differ among women undergoing laparoscopy with different endometriosis stages versus a reference group with functional ovarian follicle cysts. Peritoneal fluid from 60 women was grouped into minimal/mild (n=20), moderate/severe (n=20), and reference cysts (n=20), and ox-LDL levels were measured using enzyme immunoassay. Ox-LDL was detectable in all samples, and significantly higher ox-LDL levels were found in women with stage III/IV endometriosis compared with the reference group (p=0.03), while there was no significant difference between minimal/mild and moderate/severe stages (p=0.2) or between stage I/II endometriosis and follicle cyst controls (p=0.3). This paper is centrally about endometriosis—measuring increased oxidized LDL cholesterol in peritoneal fluid specifically in advanced-stage (stage III/IV) endometriosis.

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Abstract

INTRODUCTION: Proinflammatory and prooxidative environment in the peritoneal cavity may be involved in the pathogenesis of endometriosis. Imbalance between reactive oxygen species levels and the antioxidant capacity leads to oxidation of low-density lipoproteins (LDL). The importance of oxidized LDL (Ox-LDL) in the development of atherosclerosis is well recognized. AIM: The aim of our study was to evaluate for the presence of ox-LDL in the peritoneal fluid (PF) of women with and without endometriosis. MATERIAL AND METHODS: A total of 60 women who underwent laparoscopy were divided into groups: endometriosis sufferers with minimal to mild (n 20) and moderate to severe (n 20) stages, and the reference group (n 20) with functional follicle ovarian cysts. Oxidized LDL levels were determined in the PF using enzyme immunoassay RESULTS: Oxidized LDL levels were detectable in all peritoneal fluid samples. Significantly increased levels of ox-LDL were observed in PF of women with stage III/IV endometriosis compared to the reference group (p = 0.03). However peritoneal fluid ox-LDL concentrations did not differ significantly between patients with minimal/mild and women with moderate/severe stage of the disease (p = 0.2). No significant difference in the PF ox-LDL concentrations was also found between women with stage I/II endometriosis and patients with follicle cysts (p = 0.3). CONCLUSIONS: Increased peritoneal fluid ox-LDL levels observed in women with advanced-stage endometriosis suggest the important role of oxidative stress in the pathogenesis of the disease.
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Abstract

Summary Introduction: Proinflammatory and prooxidative environment in the peritoneal cavity may be involved in the pathogenesis of endometriosis. Imbalance between reactive oxygen species levels and the antioxidant capacity leads to oxidation of low-density lipoproteins (LDL). The importance of oxidized LDL (Ox-LDL) in the development of atherosclerosis is well recognized. Aim: The aim of our study was to evaluate for the presence of ox-LDL in the peritoneal fluid (PF) of women with and without endometriosis. Material and Methods: A total of 60 women who underwent laparoscopy were divided into groups: endometriosis sufferers with minimal to mild (n 20) and moderate to severe (n 20) stages, and the reference group (n 20) with functional follicle ovarian cysts. Oxidized LDL levels were determined in the PF using enzyme immunoassay. Results: Oxidized LDL levels were detectable in all peritoneal fluid samples. Significantly increased levels of ox-LDL were observed in PF of women with stage III/IV endometriosis compared to the reference group (p=0.03). However, peritoneal fluid ox-LDL concentrations did not differ significantly between patients with minimal/mild and women with moderate/severe stage of the disease (p=0.2). No significant difference in the PF ox-LDL concentrations was also found between women with stage I/II endometriosis and patients with follicle cysts (p=0.3). Conclusions: Increased peritoneal fluid ox-LDL levels observed in women with advanced-stage endometriosis suggest the important role of oxidative stress in the pathogenesis of the disease.

Keywords

endometriosisoxidized LDLperitoneal fluid

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Lipoproteins, LDL Oxidation-Reduction Oxidative Stress Adult Ascitic Fluid Endometriosis Endometriosis Endometrium Endometrium Enzyme-Linked Immunosorbent Assay Female Humans Lipoproteins, LDL Peritoneum Peritoneum Poland Predictive Value of Tests Severity of Illness Index

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