I405V polymorphism ofCETPgene and lipid profile in women with endometriosis

Mehdi Sahmani, Talaat Dabbaghi Ghaleh, Maryam Darabi, Masoud Darabi, Zahra Rashvand, Reza Najafipour
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 29(7) , pp. 712–715 · doi:10.3109/09513590.2013.797396 · PMID:23772784 · W1969424835
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The I405V polymorphism of the CETP gene was analyzed in women, revealing that a normal genotype homozygous for the rare allele was associated with a reduced risk of endometriosis after adjusting for BMI and lipid levels.

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Abstract

Genetic factors have an important role in the pathophysiology of endometriosis. In addition, abnormalities in lipid profile and intrinsic inflammatory status are associated with disease progression. The purpose of this study was to evaluate the effect of the I405V polymorphism of cholesteryl ester transfer protein (CETP) gene and lipid profile with the risk of endometriosis in women. Ninety-seven women with laparoscopy-diagnosed endometriosis were recruited for this study, and 107 patients with no evidence of endometriosis confirmed by laparoscopy served as controls. Samples were analyzed for polymorphism of the CETP gene using polymerase chain reaction-restriction fragment length polymorphism-based methods. After adjustment for body mass index, high-density lipoprotein-C and low-density lipoprotein-C, the risk of endometriosis in patients with normal genotype homozygous was more of the rare allele (p < 0.001, odds ratio = 0.21, 95% confidence interval = 0.09-0.45). Our results suggest that I405V polymorphism of CETP gene plays an important role as independent factor in the risk of endometriosis in women.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cholesterol Ester Transfer Proteins Endometriosis Lipids Polymorphism, Single Nucleotide Uterine Diseases Adolescent Adult Amino Acid Substitution Amino Acid Substitution Case-Control Studies Cholesterol Ester Transfer Proteins Cross-Sectional Studies Endometriosis Endometriosis Endometriosis Female Genetic Predisposition to Disease Humans Isoleucine Isoleucine

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (6)

SciLite annotations

chemicals 4
lipid lipid lipid c-glycosyltryptophan

Source provenance

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