Correlation between serum and peritoneal fluid glutathione S-transferases T1 concentration with different stages of endometriosis

Sohail Mashayekhi, Zivar Salehi, Ziba Zahiri, Ebrahim Mirzajani, Shirin Shahangian
In: Middle East Fertility Society Journal · 2017 · vol. 23(1) , pp. 23–26 · doi:10.1016/j.mefs.2017.07.003 · W2742078961
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This study measured glutathione S-transferase T1 concentrations in serum and peritoneal fluid across different endometriosis stages, finding significantly decreased levels in patients compared to controls, negatively correlating with advanced disease.

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Abstract

Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Ectopic endometrial cell proliferation and chronic inflammation in endometriosis were shown to be associated with oxidative stress (OS) induction. OS is a condition in which reactive oxygen species (ROS) overproduction and antioxidant deficiency cause a shift in oxidant/antioxidant balance. Glutathione S-transferases (GSTs) comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The aim of this project was to study the concentrations of GSTT1 in the serum and peritoneal fluid (PF) of patients with different stages of endometriosis. Frothy two PF and serum from normal and 152 from different stages of patients with endometriosis (stage I: n = 30, stage II: n = 39, stage III: n = 43 and stage IV: n = 40) were included in this study. The level of GSTT1 in the serum was determined by enzyme linked immunosorbent assay (ELISA). The results showed the presence of GSTT1 in all serum and peritoneal fluid samples, while, starting from stages I to IV endometriosis, a significant decrease in GSTT1 concentration was seen as compared to controls. It is concluded that levels of GSTT1 is negatively correlated with advanced stages of endometriosis. It is also suggested that the detection of serum and/or peritoneal fluid GSTT1 concentration may be valuable in the classifying of endometriosis.

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endometriosis

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