Association between GSTM1 gene polymorphism in Iranian patients with endometriosis

Zahra Hosseinzadeh, Farhad Mashayekhi, Ziba Zahiri Sorouri
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2010 · vol. 27(3) , pp. 185–189 · doi:10.3109/09513590.2010.488775 · PMID:20504102 · W1974792269
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Abstract

Endometriosis is defined as a condition in which tissue histologically similar to the endometrium is found outside the uterine cavity. It develops mostly in women of reproductive age. Endometriosis shows a drastically elevated frequency in industrial areas. GSTM1 gene encodes a major detoxification phase enzyme that helps detoxify various xenobiotics. Deficiency in GSTM1 activity is caused by homozygous deletion of GSTM1 and leads to various biological consequences. There are significant interethnic differences in GSTM1 allele frequencies. In this study, the relationship between GSTM1 genotypes and endometriosis in an Iranian population was investigated. The study included 120 patients and 200 healthy volunteers. Genomic DNA was prepared from peripheral blood leukocytes. Genotypes and allele frequencies were determined in patients and healthy controls using polymerase chain reaction (PCR). The GSTM1 null genotype was significantly associated with the increased risk of endometriosis (OR=3.75, 95% confidence interval (CI)=2.42-6.45, P<0.0001). The prevalence of GSTM1-null genotype in the patient group was 72.5%, compared to 40% in the control group. The proportion of GSTM1A/B genotype was higher in controls as compared to cases (20% vs. 2.5%). This study suggests that GSTM1 null genotype is associated with higher risk of endometriosis; these observations, however, requiring further confirmation in a larger multi-ethnic study.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Glutathione Transferase Adolescent Adult Chi-Square Distribution DNA DNA DNA Endometriosis Endometriosis Endometriosis Female Genetic Predisposition to Disease Genotype Glutathione Transferase Humans Iran Polymerase Chain Reaction Polymorphism, Genetic Young Adult

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