Mitochondrial DNA 4977-bp deletion in endometriosis

Elnaz Salahi, Zivar Salehi, Ziba Zahiri, Saeedeh Sadri, Niloofar Khoshdel Rad
In: Genes & Genomics · 2013 · vol. 35(5) , pp. 563–567 · doi:10.1007/s13258-013-0103-7 · W1967630528
article OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

The 4977-bp mitochondrial DNA deletion was found to be significantly more prevalent in endometriosis patients compared to controls from northern Iran.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study evaluated whether the mitochondrial DNA 4977-bp common deletion is associated with susceptibility to endometriosis in a northern Iran population by analyzing endometrial tissue DNA from 80 endometriosis cases and 100 controls. The 4977-bp deletion was detected using Gap-PCR, and it was found to occur more frequently in patients than controls (60% versus 8%), with an odds ratio of 17.25 (P < 0.0001, 95% CI 5.18–57.36). The authors interpret this as suggesting a possible role for the mtDNA 4977 deletion in endometriosis but note that larger studies are needed to confirm the finding. This paper is centrally about endometriosis — it directly tests association between the mtDNA 4977-bp deletion and endometriosis risk.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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