Glutathione S-transferase M1 polymorphism and endometriosis susceptibility: A meta-analysis

Hengyuan Li, H Li, Li H, Y Zhang, Zhang Y
Journal de gynecologie, obstetrique et biologie de la reproduction · 2014 · vol. 44(2) , pp. 136–144 · doi:10.1016/j.jgyn.2014.07.007 · PMID:25443469 · W2056137875
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This meta-analysis investigated the association between the glutathione S-transferase M1 polymorphism and endometriosis susceptibility.

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Abstract

BackgroundMany studies have investigated the association between glutathione S-transferase M1 (GSTM1) null genotype and the risk of endometriosis. However, the effect of the GSTM1 null genotype on endometriosis is still unclear because of apparent inconsistencies among those studies. A meta-analysis was performed to characterize the relationship more accurately. PubMed, Embase, and Web of Science were searched.ObjectiveTo derive a more precise estimation of the relationship, a meta-analysis was performed.MethodsWe estimated the summary odds ratio (OR) with a 95% confidence interval (95% CI) to assess the association. Up to 24 case-control studies with 2,684 endometriosis cases and 3,119 control cases were included into this meta-analysis.ResultsMeta-analysis of the 24 studies showed that GSTM1 null genotype was associated with the risk of endometriosis (random effects OR=1.66, 95% CI 1.23 to 2.24). In the subgroup analysis by ethnicity, increased risks were found for both Caucasians (OR=1.26, 95% CI 1.04-1.51) and Asians (OR=1.28, 95% CI 1.06-1.55). No evidence of publication bias was observed.ConclusionIn conclusion, this meta-analysis suggests that the GSTM1 null genotype increases the overall risk of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Glutathione Transferase Polymorphism, Genetic Adolescent Adult Case-Control Studies Endometriosis Endometriosis Female Genetic Predisposition to Disease Genotype Glutathione Transferase Humans Middle Aged Young Adult

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