No association between glutathione S-transferase M1 and T1 gene polymorphisms and susceptibility to endometriosis

Letícia Cassimiro Batista, Mariângela Torreglosa Ruiz-Cintra, Marco Fábio Prata Lima, Alessandra Bernadete Trovó de Marqui
In: Jornal Brasileiro de Patologia e Medicina Laboratorial · 2017 · doi:10.5935/1676-2444.20170024 · W2703177589
article OA: diamond CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case-control study found no association between GSTM1 and GSTT1 gene polymorphisms and endometriosis susceptibility in 132 women.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

The provided text does not contain biomedical content from the titled research paper; instead it is largely promotional material about non-Gamstop casinos, so it does not describe a study population, methods, or results regarding GSTM1/T1 polymorphisms. Because the key scientific information needed to summarize the paper’s findings is absent, no conclusions about glutathione S-transferase gene polymorphisms and endometriosis susceptibility can be derived from this input. The paper-to-paper relationship cannot be assessed beyond the mismatch between the title and the supplied content. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

ABSTRACT Introduction: Endometriosis is a common gynecologic disorder influenced by genetic and environmental factors. The glutathione S-transferase family is associated with endometriosis because its main function is cellular detoxification, so the absence of those enzymes may be a factor for the development of the disorder. Objective: Investigate the relationship between polymorphisms of GSTM1 and GSTT1 genes and endometriosis, in order to gain a better understanding of the association between detoxification genes and the susceptibility to endometriosis. Material and methods: Case-control study in 132 women (49 with endometriosis and 83 of the control group). The genotype was determined using multiplex polymerase chain reaction (PCR), observed in 10% polyacrylamide gel electrophoresis stained with silver nitrate, and statistical analysis was performed. Results: There was not a significant difference between the GSTM1 and GSTT1 null genotype in the endometriosis group and the control group (p = 0.9956). The same result was observed with the combined genotype (p = 0.8129). Conclusion: In the present study, the GSTM1 and GSTT1 polymorphisms are not associated with a higher risk of endometriosis.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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