Glutathione S-transferase M1 and T1 gene polymorphisms and risk of endometriosis in Tunisian population

Belkis Henidi, Safa Kaabachi, Marwa Mbarik, Amel Zhioua, A. Zhioua, Kamel Hamzaoui
Human fertility (Cambridge, England) · 2014 · vol. 18(2) , pp. 128–133 · doi:10.3109/14647273.2014.989925 · PMID:25549292 · W2165225093
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

The study found that GSTM1 null and GSTT1 null genotypes were significantly associated with an increased risk of endometriosis in the Tunisian population, particularly when both null genotypes were present.

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Abstract

OBJECTIVE: An association between endometriosis and the glutathione S-transferase M1 (GSTM1)- and GSTT1-related genes has been proposed on account of the detoxification properties of the GST enzymes. The aim of the present study was to investigate whether the polymorphisms and null mutations are associated with the susceptibility to endometriosis. METHODS: The study included 105 women with endometriosis and 150 healthy women with no laparoscopic evidence of disease. Genotyping of the GSTM1 and GSTT1 gene polymorphisms was performed by Multiplex-PCR. RESULTS: There was a significant association of GSTM1 null and GSTT1 null genotypes with endometriosis both when studied alone (P = 0.001 and P = 0.03, respectively) and in combination (P = 0.00002). CONCLUSION: The findings suggest that the GSTM1 and GSTT1 gene deficiency predisposes to endometriosis in a Tunisian population and can confer a significant increased risk when the GST null genotypes are combined.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Glutathione Transferase Adult Case-Control Studies Endometriosis Female Genetic Predisposition to Disease Genotype Glutathione Transferase Humans Polymorphism, Genetic Tunisia

Citation neighborhood

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