[Association between glutathione S-transferase M1 gene deletion and genetic susceptibility to endometriosis].

Dong-xian Peng, Dongxian Peng, Yuanli He, Yuan-li He, Li-wen Qiu, Liwen Qiu, Fang Yang, Jing-ming Lin
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA · 2003 · vol. 23(5) , pp. 458–9, 462 · PMID:12754129 · W2265524361
article OA: closed CC0 ⤵ 10 in-corpus citations
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This study found that the glutathione S-transferase M1 (GSTM1) gene deletion is associated with an increased risk of endometriosis in women of Han nationality in Guangdong Province.

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Abstract

OBJECTIVE: To evaluate the possible association of the glutathione S-transferase M1 (GSTM1) gene polymorphism with the susceptibility to endometriosis in women of Han nationality in Guangdong Province. METHODS: Polymerase chain reaction was used to identify the GSTM1 genotypes in 76 patients with endometriosis and 80 controls (surgical patients for gynecological problems other than endometriosis). RESULTS: The frequencies of the GSTM1 null genotypes in patients with endometriosis and controls were 65.8% and 46.3%, respectively, showing a significant difference between the endometriotic cohort and the control group (X(2)=6.03, P < 0.05). Individuals with GSTM1 null genotype were exposed to risks for endometriosis 2.24 times that of subjects without these genotypes OR=2.24, 95% CI=1.17-4.27 . CONCLUSION: GSTM1 gene deletion might bea risk factor for endometriosis in women of Han nationality who are native residents in Guangdong Province.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Glutathione Transferase Adult Endometriosis Endometriosis Female Glutathione Transferase Humans Middle Aged

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