[Association between glutathione S-transferase M1 gene deletion and genetic susceptibility to endometriosis]
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⤵ 10 in-corpus citations
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This study found that the glutathione S-transferase M1 (GSTM1) gene deletion is associated with an increased risk of endometriosis in women of Han nationality in Guangdong Province.
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Abstract
OBJECTIVE: To evaluate the possible association of the glutathione S-transferase M1 (GSTM1) gene polymorphism with the susceptibility to endometriosis in women of Han nationality in Guangdong Province.
METHODS: Polymerase chain reaction was used to identify the GSTM1 genotypes in 76 patients with endometriosis and 80 controls (surgical patients for gynecological problems other than endometriosis).
RESULTS: The frequencies of the GSTM1 null genotypes in patients with endometriosis and controls were 65.8% and 46.3%, respectively, showing a significant difference between the endometriotic cohort and the control group (X(2)=6.03, P < 0.05). Individuals with GSTM1 null genotype were exposed to risks for endometriosis 2.24 times that of subjects without these genotypes OR=2.24, 95% CI=1.17-4.27 .
CONCLUSION: GSTM1 gene deletion might bea risk factor for endometriosis in women of Han nationality who are native residents in Guangdong Province.
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Cited by (10)
- Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population 2016
- Association between glutathione S-transferase M1/T1 gene polymorphisms and susceptibility to endometriosis: A systematic review and meta-analysis 2016
- Glutathione S-transferase M1 polymorphism and endometriosis susceptibility: a meta-analysis 2014
- Genetic association studies in female reproduction: from candidate-gene approaches to genome-wide mapping 2013
- CYP1A1 and GSTM1 genes polymorphism and its association with endometriosis : A pilot study 2013
- No association of GSTM1 null polymorphism with endometriosis in women from central and southern Iran 2012
- The CYP1A1 and GSTM1 Genetic Polymorphisms and Susceptibility to Endometriosis in Women from South India 2009
- Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis 2008
- The search for genes contributing to endometriosis risk 2008
- Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis of genetic association studies 2005
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- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T21:01:06.509505+00:00
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