Polymorphism of catalase gene (CAT C-262T) in women with endometriosis

Samin Sabouhi Zarafshan, S Sabouhi Zarafshan, Zivar Salehi, Z Salehi, E Salahi, Elnaz Salahi, E Eskafi Sabet, S Shabanipour, Ziba Zahiri, Z Zahiri
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2014 · vol. 35(3) , pp. 269–271 · doi:10.3109/01443615.2014.948402 · PMID:25154023 · W2147414542
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found a significant association between the catalase C-262T gene polymorphism and an increased risk of endometriosis in women.

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Abstract

Endometriosis is defined as the presence of ectopic endometrial glands and stroma outside of the uterine cavity. Recent studies have shown that the oxidative stress causes irreparable damage, which leads to oxidative enzymopathies. Catalase gene encodes an antioxidant enzyme, detoxifying hydrogen peroxide to H2O and O2. The aim of this study was to determine whether the polymorphism at position -262 in the promoter region of catalase gene (C-262T), which alters the expression and enzyme blood levels, could have an impact on the risk of endometriosis. Extracted DNA from peripheral blood leucocytes was genotyped using allele-specific PCR (AS-PCR). The χ(2)-test was used for statistical analyses. In endometriosis subjects, the frequencies of the CAT CC/CT/TT were 67.5%, 32.5% and 0%, respectively, while in healthy women, they were 12%, 68% and 20%, respectively. Significant differences in allele and genotype distribution among controls and patients were found (OR, 178.76 95% CI, 10.11-3159.1202; p = 0.0004). This study indicates that catalase C-262T polymorphism is associated with the endometriosis. Randomised multicentre trials with greater sample sizes are still needed to clarify our results.

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Condition tags

endometriosis

MeSH descriptors

Catalase Endometriosis Adult Alleles Case-Control Studies Catalase Endometriosis Female Genotype Humans Polymorphism, Genetic Promoter Regions, Genetic Young Adult

Citation neighborhood

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