Glutathione- S -transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis in Chinese populations

Chen XP, Xinping Chen, Xin-Ping Chen, Da-Feng Xu, Dafeng Xu, Xu DF, Wei-Hua Xu, Weihua Xu, Xu WH, Jia Yao, Yao J, Sheng-Miao Fu, Fu SM, Shengmiao Fu
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2015 · vol. 31(11) , pp. 840–845 · doi:10.3109/09513590.2015.1080681 · PMID:26370772 · W1633375567
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This meta-analysis of Chinese populations found that the null genotype of GSTM1 and GSTT1 significantly correlates with an increased risk of endometriosis.

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Abstract

In view of the controversies surrounding the glutathione-S-transferases (GST) M1/T1-endometriosis association, a meta-analysis of the GSTM1/GSTT1 genetic association studies of endometriosis was performed in Chinese populations. PubMed, Springer Link, OvidSP, and Chinese databases were searched for related studies. A total of nine studies on GSTM1-endometriosis involved 874 cases and 997 controls, and five studies on GSTT1 involved 404 cases and 513 controls were included in this meta-analysis. Overall, the null genotype of GSTM1/GSTT1 was significantly related to endometriosis risk in Chinese populations (GSTM1, OR = 2.21, 95% CI: 1.22-4.01; GSTT1, OR = 2.31, 95% CI: 1.34-3.99). In subgroup analyses stratified by ethnicity and source of controls, the same results were observed in Chinese Han and population-based studies. The sensitivity analysis confirmed the reliability and stability of the meta-analysis. No publication bias was found among studies by Egger's test. In conclusion, our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to endometriosis in Chinese populations, especially in Chinese Han.

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Condition tags

endometriosis

MeSH descriptors

Asian People Endometriosis Glutathione Transferase Asian People China Endometriosis Female Genetic Predisposition to Disease Genotype Glutathione Transferase Humans Polymorphism, Genetic Polymorphism, Single Nucleotide

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