Analysis on the relationship between polymorphism of Exon7 situs in CYP1A1 gene,GSTM1 gene and susceptibility of endometriosis in women of Han nationality in Jilin city

Objective:To explore the relationship between polymorphism of Exon7 situs(Ile-Val situs) in CYP1A1 gene,GSTM1 gene and susceptibility of endometriosis in women of Han nationality in Jilin city.Methods:The expression of polymorphisms of Exon7 situs(IleVal situs) in CYP1A1 gene,GSTM1 gene of 216 cases with endometriosis and 216 healthy women were detected by polymerase chain reaction(PCR).Results:The frequencies of GSTM1-null genotype in endometriosis group and control group of Han nationality were 0.667 and 0.463,respectively,there was significant difference(P0.05),the risk of GSTM1-null genotype to endometriosis was 1.896 times higher than that of GSTM1+ to endometriosis;there was difference in the distribution frequencies of three genotypes of Ile/Val between control group and endometriosis group(P0.05);the risk of Ile/Val and Val/Val to endometriosis was 1.901 and 3.056 times higher than that of Ile/ Ile genotype to endometriosis;the OR of CYP1A1 Ile/Val combined with GSTM1 null genotypes was 3.409(95% CI:1.897~6.125,P0.01),while the OR of CYP1A1 Val/Val combined with GSTM1 null genotypes was 7.143(95% CI 2.584~19.742,P0.01).Conclusion:Ile/Val and Val/Val genotypes and GSTM1-null genotype are related to the susceptibility of endometriosis,which might be one of the risk factors of endometriosis.