Chemotaxis of macrophages by a peritoneal fluid protein in women with endometriosis

S J Weil, Weil SJ, Stacie J. Weil, Shi‐Yi Wang, S Wang, Wang S, María Claudia Pérez, M C Perez, Perez MC, C. Richard Lyttle, Lyttle CR, C R Lyttle
Fertility and Sterility · 1997 · vol. 67(5) , pp. 865–869 · doi:10.1016/s0015-0282(97)81398-2 · PMID:9130891 · W2079739575
article OA: bronze CC0 ⤵ 30 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper investigated the chemotactic properties of a peritoneal fluid protein in women with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo expand on a preliminary study comparing the chemotactic potential of peritoneal fluid (PF) from women with and without endometriosis and to characterize this activity via immunosuppressants and a protease.DesignCase control study.SettingUniversity center.Patient(s)Fifty-nine women with endometriosis and 44 without, undergoing laparoscopy.Intervention(s)Collection of PF, endometriotic, ovarian, and endometrial biopsies at laparoscopy.Main outcome measure(s)Chemotactic activity of PF was tested via an in vitro assay alone and in the presence of immunosuppressants cyclosporin A (CSA), FK506, rapamycin, and type XVII-b(S-V8) protease and in media incubated with endometriotic, ovarian, or endometrial biopsy specimens.Result(s)The PF from women with endometriosis had significantly greater chemotactic activity (cells per well, mean +/- SD) than without endometriosis (142 +/- 39 versus 48 +/- 17). Cyclosporin A significantly inhibited the chemotactic activity of the endometriotic PF; FK506 and rapamycin did not. Incubation of media with endometriotic tissue, but not ovarian or endometrial, for > or = 7 hours displayed chemotactic activity. Protease type XVII-b(S-V8) added to endometriotic PF inhibited this chemotactic activity.Conclusion(s)Peritoneal fluid from patients with endometriosis contains a protein chemotactic factor attracting inflammatory cells into the peritoneal cavity, possibly secreted by endometriotic implants. This chemotactic factor may be a member of the immunophilin family because of its inhibition profile.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemotaxis Endometriosis Macrophages Proteins Ascitic Fluid Case-Control Studies Cyclosporine Cyclosporine Endometriosis Female Humans Immunosuppressive Agents Immunosuppressive Agents Macrophages N-Formylmethionine Leucyl-Phenylalanine N-Formylmethionine Leucyl-Phenylalanine Polyenes Polyenes Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (30)

Source provenance

europepmc
last seen: 2026-07-27T06:15:28.040536+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:10:52.568893+00:00
License: CC0 · commercial use OK