Identifying Chinese Herbal Medicine Network for Endometriosis: Implications from a Population‐Based Database in Taiwan

Pei-Ju Tsai, Yi‐Hsuan Lin, Jiun-Liang Chen, Sien-Hung Yang, Sien‐Hung Yang, Yu‐Chun Chen, Hsing‐Yu Chen
Evidence-based complementary and alternative medicine : eCAM · 2017 · vol. 2017(1) , pp. 7501015 · doi:10.1155/2017/7501015 · PMID:28740539 · W2732497722
article OA: hybrid CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study analyzed 12,986 prescriptions from a Taiwanese database to identify Gui-Zhi-Fu-Ling-Wan and Cyperus rotundus as core Chinese herbal medicines used for endometriosis.

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Abstract

Background . Endometriosis is a common but bothersome gynecological disease, and Chinese herbal medicine (CHM) is used for treating endometriosis. The aim of this study is to explore CHM network and core treatments for endometriosis by analyzing nationwide CHM prescription database. Methods . From 1998 to 2013, the CHM prescriptions made primarily for endometriosis among women diagnosed with endometriosis (ICD‐9‐CM code: 671) by gynecologists during their reproductive age were collected. CHM network analysis was then carried out by using association rule mining and social network analysis. Results . A total of 12,986 CHM prescriptions made for endometriosis were analyzed. There were 556 kinds of CHM ever used, and, in average, each prescription was composed of 6.2 CHMs. Gui‐Zhi‐Fu‐Ling‐Wan (GZFLW) was used most frequently, followed by Cyperus rotundus (28.1% and 18.8% of all prescriptions, resp.) . Additionally, the combination of Cyperus rotundus with GZFLW (8.0%) was the most frequently used combination of two CHMs . CHM network showed that GZFLW was the core CHM for endometriosis and graphically demonstrated the extensive coverage of TCM syndromes and pathogenesis of endometriosis. Conclusions . CHM network provides graphical demonstration and summary of commonly used CHMs for endometriosis, and further studies are warranted based on these findings.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (59)

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SciLite annotations

organisms 27
cyperus rotundus cyperus rotundus noordeloos 2009062 plants true insects multicellular animals cyperus rotundus yuzu corydalis yanhusuo yi mu cao cyperus rotundus sparganium stoloniferum curcuma corydalis yanhusuo cyperus rotundus sparganium stoloniferum curcuma corydalis yanhusuo typha angustifolia trogopterus xanthipes verbesina prostrata ligustrum lucidum cyperus rotundus cyperus rotundus corydalis yanhusuo verbesina prostrata ligustrum lucidum
chemicals 4
danazol medroxyprogesterone acetate carbonate mineral

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