Effect of the herbal medicine of Huoxue Xiaoyi Decoction on the rat model of recurrence of endometriosis

Objective: To check feasibility of rat model of recurrent risk of endometriosis and observe the effects of Huoxue Xiaoyi Decoction on volume and morphology changes of planting oven in the model.Methods: The model was made by auto-uterus subcutaneous transplantation and administered in the first day after operation to simulate the environment of recurrent risk of endometriosis.Planting oven volume and inner membrance tissue form of all groups rats were observed on the whole and by light microscopy.Results: The difference of the ectopic endometrial volumes was significant between Huoxue Xiaoyi Decoction group and model group at drug administration 3 weeks and after drug withdrawal 3 weeks(P0.05).Glandular epithelium cells of the ectopic endometrium of the Huoxue Xiaoyi Decoction group were flat,their glandular cavities were small,and the numbers of their glandular bodies were decreased.Conclusion: The method of simulating recurrent risk of endometriosis,which established the model of endometriosis and administered drugs at the first day after operation,was feasible.Huoxue Xiaoyi Decoction possessed preferable and Durable inhibitory effects on recurrence of ectopia mass.