Chinese medicine improves postoperative quality of life in endometriosis patients: A randomized controlled trial

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This study randomized 320 endometriosis patients to receive either traditional Chinese medicine or Western medicine post-surgery, finding Chinese medicine led to greater improvements in quality of life.

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This randomized controlled trial studied whether Chinese medicine (CM) versus Western medicine (WM) improves quality of life (QOL) after conservative surgery in 320 endometriosis patients using a random block design. After surgery, patients received either CM aimed at “activating blood circulation and removing blood stasis” based on syndrome differentiation or WM consisting of gonadotropin-releasing hormone agonist or gestrinone for 3–6 months, with QOL assessed pre- and posttreatment using the WHOQOL-BREF. The paper reports that in the CM group physical, psychological, and environmental QOL scores increased significantly and that 12 specific WHOQOL items and overall health/QOL improved, while the WM group showed significant changes in fewer items; posttreatment comparisons favored CM on physical health and several CM-specific domains including mobility, activities of daily living, and sexual activity. This paper’s main topic is endometriosis—specifically, CM versus WM effects on postoperative quality of life in endometriosis patients.

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Abstract

ObjectiveTo investigate the effect of Chinese medicine (CM) and Western medicine (WM) on quality of life (QOL) after conservative surgery for endometriosis.MethodsA total of 320 patients with endometriosis were randomized into two groups by using random block design, CM group (160 cases, activating blood circulation and removing blood stasis treatment based on syndrome differentiation) and WM group (160 cases, gonadotropin-releasing hormone agonist or gestrinone treatment) after conservative surgery. Treatment was given for 3-6 months (according to the revised American Fertility Society scoring system stage), and the World Health Organization QOL-BREF (WHOQOL-BREF) was applied to patients before and after treatment to assess QOL.ResultsThere were 136 cases in the CM group and 141 cases in the WM group completing therapy. In the CM group, the use of the WHOQOL-BREF showed that the physical, psychological and environmental scores posttreatment were significantly higher than those at pre-treatment (P < 0.05), and for 12 items (pain and discomfort, energy and fatigue, sleep and rest, mobility, activities of daily living, work capacity, negative feelings, health and social care: accessibility and quality, participation in and opportunities for recreation/leisure activities, appetite, QOL score, overall health status and QOL), the difference in scores was significant (P < 0.05). In the WM group, 4 items (pain and discomfort, opportunities for acquiring new information and skills, QOL score, overall health status and QOL) had significantly different scores post-treatment compared with those at pre-treatment (P 0.05). After treatment, the scores for physical health in the CM group were significantly higher than those of the WM group (P < 0.05) and the scores of 4 items (mobility, activities of daily living, sexual activity, QOL score) in the CM group were significantly higher than those in the WM group (P < 0.05).ConclusionsCM and WM treatment could improve the QOL of patients with endometriosis after conservative surgery. CM treatment is more effective than WM.
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Abstract

Objective To investigate the effect of Chinese medicine (CM) and Western medicine (WM) on quality of life (QOL) after conservative surgery for endometriosis.

Methods

A total of 320 patients with endometriosis were randomized into two groups by using random block design, CM group (160 cases, activating blood circulation and removing blood stasis treatment based on syndrome differentiation) and WM group (160 cases, gonadotropin-releasing hormone agonist or gestrinone treatment) after conservative surgery. Treatment was given for 3–6 months (according to the revised American Fertility Society scoring system stage), and the World Health Organization QOL-BREF (WHOQOL-BREF) was applied to patients before and after treatment to assess QOL.

Results

There were 136 cases in the CM group and 141 cases in the WM group completing therapy. In the CM group, the use of the WHOQOL-BREF showed that the physical, psychological and environmental scores posttreatment were significantly higher than those at pre-treatment (P<0.05), and for 12 items (pain and discomfort, energy and fatigue, sleep and rest, mobility, activities of daily living, work capacity, negative feelings, health and social care: accessibility and quality, participation in and opportunities for recreation/leisure activities, appetite, QOL score, overall health status and QOL), the difference in scores was significant (P<0.05). In the WM group, 4 items (pain and discomfort, opportunities for acquiring new information and skills, QOL score, overall health status and QOL) had significantly different scores post-treatment compared with those at pre-treatment (P0.05). After treatment, the scores for physical health in the CM group were significantly higher than those of the WM group (P<0.05) and the scores of 4 items (mobility, activities of daily living, sexual activity, QOL score) in the CM group were significantly higher than those in the WM group (P<0.05).

Conclusions

CM and WM treatment could improve the QOL of patients with endometriosis after conservative surgery. CM treatment is more effective than WM. Similar content being viewed by others

References

Endometriosis Group, Special Committee of Obstetrics and Gynecology, Chinese Medical Association. Endometriosis diagnosis and treatment guidelines. Chin J Obstetr Gynecol (Chin) 2007;42:645–648. Cao ZY. Chinese obstetrics and gynecology. 2nd ed. Beijing: People’s Medical Publishing House; 2004:1265. Ministry of Health of the People’s Republic of China. Guidelines for clinical research of new drugs of traditional Chinese medicine. 1st ed. Beijing: China Medical Science Press;1993:267. Zhang YZ, ed. Chinese gynecology. 1st ed. Beijing: China Press of Traditional Chinese Medicine;2002:131–133. American Fertility Society. Revised American Fertility Society classification of endometriosis: 1985. Fertil Steril 1985;43:351–352. Hao YT, Fang JQ. The int roduce and usage of WHOQOL instrument in Chinese. Modern Rehabil (Chin) 2000;8:1127–1129. Zhou YF, CuiI H, Qiao J, Fu Q, Liao QP, Wang JL, et al. Should pay attention to the ustandardization of the diagnosis and treatment of endometriosis. Chin J Clin Obstetr Gynecol (Chin) 2001;2:68–71. Xiong YH, Zhu B, Ling Y. Comparison of clinical effect of different drug in the treatment of endometriosis after laparoscopy. Progr Obstetr Gynecol (Chin) 2005;14:492–494. Sun WW, Zhao RH, Li JQ, Wu Y. Clinical observation on Chinese medicine treatment of endometriosis. Chin J Inf Tradit Chin Med (Chin) 2009;16:70–71. Huang XY. The clinical research of nourishing yin and supplementing yang sequentially to prevent form recurrence of endometriosis. J Nanjing Univ Chin Med (Chin) 2011:3–4. Zhang TY, Fu AZ, Zhang Fl, Li YJ, Yan ZH. Clinical study of efficacy of GnRH-a combined with add back therapy in the treatment of advanced endometriosis after conservative laparoscopic operation. Matern Child Health Care China (Chin) 2007;33:4669–4672. Tong JL, Lang JH, Leng JH, Liu ZF, Sun DW, Zhu L, et al. Effect of addback therapy on gonadotropin-releasing hormone analogues treatment for severe endometriosis after laparoscopic surgery. Progr Obstet Gynecol (Chin) 2008;17:839–842. Cui J, Chen H. Efficacy of GnRH-a and gestrinone to prevent postoperative endometriosis recurrence. J Modern Clin Med (Chin) 2009;4:296–297. Ai L, Zhao RH. Professor Li Guangrong’s experience in the treatment of pelvic endometriosis. Chin J Inf Tradit Chin Med (Chin) 2005;12(11):87–88. Fang JQ, Wan CH, Shi ML, Liu FB. An introduction to study on quality of life and measurement scales. Modern Rehabil (Chin) 2000;4:1127–1129,1145. Hao YT, Fanc JQ, Power MJ, Wu SM, Zhu SM. The equivalence of WHOQOL-BREF among 13 culture versions. Chin Ment Health J (Chin) 2006;2:71–75. Author information Authors and Affiliations Corresponding author Additional information Supported by the “Eleventh-Five” National Technology Support Program Project (No. 2006BAI04A17) Rights and permissions About this article Cite this article Zhao, Rh., Liu, Y., Tan, Y. et al. Chinese medicine improves postoperative quality of life in endometriosis patients: A randomized controlled trial. Chin. J. Integr. Med. 19, 15–21 (2013). https://doi.org/10.1007/s11655-012-1196-6 Received: Published: Issue date: DOI: https://doi.org/10.1007/s11655-012-1196-6

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endometriosis

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Gonadotropin-Releasing Hormone Postoperative Pain Quality of Life Adolescent Adult China Drugs, Chinese Herbal Endometriosis Endometriosis Female Follow-Up Studies Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Middle Aged Pain Measurement Patient Satisfaction Patient Satisfaction

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