The effect of Chinese herbs on the cytokines of rats with endometriosis

Qu F, Fan Qu, Jue Zhou, Zhou J, Ma B, Baozhang Ma, MA Bao-zhang
Journal of alternative and complementary medicine (New York, N.Y.) · 2005 · vol. 11(4) , pp. 627–630 · doi:10.1089/acm.2005.11.627 · PMID:16131286 · W1980124798
Lab / animal OA: closed CC0 ⤵ 9 in-corpus citations
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YiWeiNing treatment reduced elevated TNF-alpha, IL-6, and IL-8 levels in rats with endometriosis, suggesting inhibition of ectopic endometrial growth.

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Abstract

OBJECTIVE: The aim of this study was to study the regulatory function of Chinese medicine-YiWeiNing (YWN) on the cytokines of endometriosis (EM) model rats. MATERIALS AND METHODS: After successfully creating EM models of rats, all were separated randomly into five groups: high dose of YWN (5.4 g/100 g), low dose of YWN (1.8 g/100 g), Danazol group (3.6 mg/100 g), a model group, and a false-operation group. They were then reviewed for the variation of the amount of TNF-alpha (tumor necrosis factor-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8). RESULTS: The content of TNF-alpha, IL-6, and IL-8 in the peripheral blood of the model group was apparently higher than the false-operation group (p < 0.01), and YWN reduced the amount of TNF-alpha, IL-6, and IL-8 in the serums of the model group's rats. This made these cytokines tend toward normal levels without an apparent variation, when compared with the false-operation group (p > 0.05). CONCLUSIONS: YWN can prevent the growth of ectopic endometrium by inhibiting the synthesis and secretion of TNF-alpha, IL-6, and IL-8.

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Condition tags

endometriosis

MeSH descriptors

Cytokines Cytokines Drugs, Chinese Herbal Endometriosis Endometriosis Phytotherapy Phytotherapy Animals Animals Cytokines Cytokines Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Cited by (9)

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