Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis

Aude Beliard, Aude Béliard, Beliard A, Agnès Noël, Agnes Noël, Goffin F, Frederic Goffin, Frédéric Goffin, Françis Frankenne, Francis Frankenne, Frankenne F, Foidart JM, Jean-Michel Foidart, Jean‐Michel Foidart
Fertility and sterility · 2003 · vol. 79 , pp. 724–729 · doi:10.1016/s0015-0282(02)04819-7 · PMID:12620483 · W2142918455
article OA: bronze CC0 ⤵ 27 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study developed an in vitro model using 111Indium-tropolonate labeled endometrial cells to investigate their adhesion to the peritoneum, offering a new approach to studying endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo evaluate, in a new original in vitro assay, putative factors that could modulate the adhesion of endometrial cells to peritoneum.DesignProspective, controlled in vitro study.SettingAcademic research laboratory.Patient(s)Fourteen nonmenopausal women undergoing hysterectomy or laparoscopy for benign gynecologic indication.Intervention(s)Endometrial cells obtained from women with regular cycles without endometriosis were labeled with 111Indium and confronted in vitro with mouse peritoneum in the presence of various cytokines and/or antiadhesive compounds.Main outcome measure(s)Radioactivity in 111Indium-labeled endometrial cells.Result(s)The adhesion of human endometrial cells to mouse peritoneum was increased by treatment with pro-inflammatory cytokines (interleukin IL-1beta, IL-6, TNF alpha, TGF-beta1). Whereas heparan sulfate had no effect on cell adhesion, a gel of ferric hyaluronate (Intergel) was able to counteract the pro-adhesive effect of cytokines. Interestingly, the pretreatment of peritoneum with cytokines, 24 hours before cell seeding in the presence of the ferric hyaluronate gel, restored the cytokine-promoting effect on cell adhesion.Conclusion(s)Proinflammatory cytokines promote the in vitro peritoneal adhesion of endometrial cells. An antiadhesive hyaluronate gel used in clinics decreases the adhesion in a dose-dependent manner and reduces cytokine bioavailability.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Organometallic Compounds Peritoneum Tropolone Tropolone Adult Animals Cell Adhesion Cell Adhesion Cell Adhesion Cytokines Cytokines Endometriosis Endometrium Endometrium Female Gels Humans Hyaluronic Acid

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (27)

Source provenance

europepmc
last seen: 2026-09-21T06:08:07.822426+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:12:55.732728+00:00
License: CC0 · commercial use OK