Pathogenèse de l'endométriose

Endometriosis; Angiogenesis; Lymphangiogenesis; Inflammation; Fibrosis

[en] Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynecological history and a careful clinical examination should be done as early as possible in order to treat patients correctly. Medical treatment is not appropriate in all cases and surgical treatment should be proposed but morbidity is related to the severity of the lesion. Ectopic implantation of endometrial cells needs complex interactions between host tissue and epithelial endometrial cells. The conditions for the development of endometriosis are estrogeno-dependent growth of endometrial cells, induction of angiogenesis and lymphangiogenesis. Principal cellular and molecular factors of angiogenesis, lymphangiogenesis and fibrosis should be identified in order to develop new therapeutic strategies of endometriosis. Disciplines : Reproductive medicine (gynecology, andrology, obstetrics) Nisolle, Michelle ; Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR Alvarez Gonzalez, Maria-Luz ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement Colombo, M. Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique Language : French Title : Pathogenèse de l'endométriose Alternative titles : [en] Pathogenesis of Endometriosis Publication date : September 2007 Journal title : Gynécologie Obstétrique et Fertilité ISSN : 1297-9589 Publisher : Elsevier Science Volume : 35 Issue : 9 Pages : 898-903 Peer reviewed : Peer Reviewed verified by ORBi Available on ORBi : since 22 June 2009 Scopus citations® 32 Scopus citations® without self-citations without self-citations 25 OpenAlex citations 24 - Sampson J.A. 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