POLYMORPHISM OF THE Р53-GENE IN GENITAL ENDOMETRIOSIS Naslednikova I.O., Ilyadi E.B., Urazova O.I., Tkachev V.N.,

V. V. Novitsky
2013 · W2527851140
article OA: closed CC0 Metadata only
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found a statistically significant increase in the frequency of the "pathological" allele C and genotype CC of the p53 gene's G72C polymorphism in women with genital endometriosis, associating them with disease risk and severity.

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Abstract

The research is conducted using up-to-date molecular-genetic methods of alleles and genotypes of polymorphous variant of G72C gene distribution at 200 females with genital endometriosis and 100 salutary females in Tomsk region. At patients with genital endometriosis statistically signifi cant increase in frequency of «pathological» allele from polymorphism G72C of р53 gene is revealed. It is specifi ed that the risk of genital endometriosis development is connected with allele C and a genotype CC polymorphic variant G72C of р53 gene in a genotype of female. Susceptibility to the severe course of genital endometriosis (3-4 extent distribution of process according to classifi cation of the American Society of a Fertility RAF-S) is associated with allele C and a genotype CC polymorphism G72C of р53 gene.

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endometriosis

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