Pathological evaluation of the rat endometriosis model

Ichiro Uchiide, Uchiide I, Ihara T, Tomomi Ihara, Masao Sugamata, Sugamata M
Fertility and sterility · 2002 · vol. 78(4) , pp. 782–786 · doi:10.1016/s0015-0282(02)03327-7 · PMID:12372457 · W2158642338
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This paper describes the pathological evaluation of a rat endometriosis model to assess its suitability for research purposes.

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Abstract

OBJECTIVE: To observe in detail the morphology of experimental rat endometriosis, specifically in peritoneum adjacent to uterine transplants attached via autotransplantation. DESIGN: Light and electron microscopic study. SETTING: Tochigi Institute of Clinical Pathology, Japan. ANIMAL(S): Female-SD rats maintained on a schedule of 12 hours of light and 12 hours of dark for 2 weeks. INTERVENTION(S): Uterine transplants were attached to rat peritoneum via the surgical autotransplantation technique. The implanted area of peritoneum, including abdominal muscle, were excised from anesthetized rats at four (n = 10), seven (n = 10), and 14 (n = 10) days after uterine autotransplantation. The mesenteries were autotransplanted as a comparative control. MAIN OUTCOME MEASURE(S): We examined the morphologic alterations of uterus-attached peritoneum following the time interval after the implantation. RESULT(S): In rat endometriosis models, the stromal tissue of uterus-attached peritoneum showed proliferation and infiltration of mast cells, eosinophils, plasma cells, lymphocytes, and macrophages. These lesions increased with time after implantation; however, ultimately these infiltrating cells disappeared and proliferation declined. CONCLUSION(S): Our findings suggest that uterine autotransplantation induces the infiltration of allergic inflammatory-related cells and proliferative lesions in peritoneal stroma attached endometrium. These data should prove useful for investigations of human endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Disease Models, Animal Endometriosis Animals Animals Endometriosis Endometriosis Endometriosis Eosinophils Eosinophils Eosinophils Female Female Lymphocytes Lymphocytes Lymphocytes Macrophages Macrophages Macrophages Mast Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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