The effects of levamisole on experimental endometriosis: a randomized controlled trial in a rat model

Afshin Azimirad, Saeed Alborzi, Perikala Vijayananda Kumar, Perikala V. Kumar, Afsoon Zarei, Mina Azimirad
Archives of gynecology and obstetrics · 2013 · vol. 288(6) , pp. 1301–1308 · doi:10.1007/s00404-013-2895-8 · PMID:23712737 · W2003213699
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Levamisole treatment in a rat endometriosis model reduced leukocytes and lymphocytes and showed a trend toward improved histopathology and cytokine profiles.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This randomized, placebo-controlled, double-blind rat trial studied whether levamisole affects experimentally induced endometriosis, assessing implant histopathology plus peritoneal cytokines (interleukin-6, vascular endothelial growth factor-A, tumor necrosis factor-alpha) and blood leukocyte and lymphocyte counts at healthy, endometriotic, and post-treatment time points. Twenty-two Sprague–Dawley rats with normal estrus cycles were allocated to levamisole (5 mg/rat/day) or placebo after induction of endometriosis, with necropsy after 6 weeks and ELISA measurements from blood samples and peritoneal wash. Implant histopathology showed a descriptive reduction with levamisole but did not reach statistical significance (p=0.065), while post-treatment leukocyte and lymphocyte comparisons differed significantly between groups (both with lower counts in the levamisole group), and cytokine results were mostly—but not fully—in favor of levamisole. The paper explicitly notes a need for further studies, including assessing higher levamisole doses. This paper is centrally about endometriosis — it tests levamisole efficacy in a randomized rat model of experimental endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adjuvants, Immunologic Endometriosis Levamisole Adjuvants, Immunologic Animals Double-Blind Method Endometriosis Endometriosis Female Humans Immunomodulation Interleukin-6 Interleukin-6 Leukocytes Levamisole Peritoneum Peritoneum Prospective Studies Rats Rats, Sprague-Dawley

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