Comparing the effects of Triptorelin and Calendula officinalis on size and pathology of induced endometriosis in rats

Tahereh Poordast, Fatemeh Sadat Najib, Nader Tanide, Afsoon Kanani, Maral Mokhtari, Kefayat Chamanara
In: Journal of Endometriosis and Pelvic Pain Disorders · 2019 · vol. 11(3) , pp. 132–136 · doi:10.1177/2284026519855293 · W2950935729
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Triptorelin significantly reduced the size and pathology of induced endometriosis in rats, while Calendula officinalis at the tested doses did not show significant effects compared to the control group.

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Abstract

Background: Endometriosis is defined as the growth of endometrial glands and stoma extra-uterine sites. It is an estrogen-dependent inflammatory disease estimated to affect 10% of women of reproductive age. This study aimed at comparing the effects of Triptorelin and Calendula officinalis on the induced endometriosis in female rats. Materials and Methods: In this experimental study in an animal model, 52 rats with induced endometriosis were divided into four groups. The control group was treated with 0.5 mL/kg normal saline orally, the second group with single intramuscular injection of Triptorelin S.R.11.25 (3 mg/kg), the third group with Calendula 1000 mg/kg, and the fourth group with Calendula 2000 mg/kg for 6 weeks. The mean area and volume of endometriosis and pathological scores of endometriotic implants were compared between groups. Results: After 6 weeks of treatment, Triptorelin was able to reduce the mean area and volume of endometriotic implants (p < 0.05), but Calendula did not have a significant effect compared to the control group. Mean rank of pathologic score in Triptorelin group had a significant difference with the control group and Calendula 1000 mg/kg (adjusted α < 0.001, adjusted α = 0.004). There was no significant difference in score between the control group and Calendula 1000 mg/kg and 2000 mg/kg. Conclusion: Based on our findings in the used doses, Calendula was not effective for the treatment of experimental endometriosis in rats.

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endometriosis

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