Postoperative hormonal therapy after surgical excision of deep endometriosis

Edgardo Somigliana, Andrea Busnelli, Laura Benaglia, Paola Viganò, Leonardi M, Marta Leonardi, M. Leonardi, Alessio Paffoni, Paolo Vercellini
European journal of obstetrics, gynecology, and reproductive biology · 2016 · vol. 209 , pp. 77–80 · doi:10.1016/j.ejogrb.2016.03.030 · PMID:27067871 · W2324573408
editorial OA: closed CC0 ⤵ 24 in-corpus citations
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This study investigated the efficacy of postoperative hormonal therapy following surgical excision of deep endometriosis to manage pain and recurrence.

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Abstract

The clinical management of women with deep peritoneal endometriosis remains controversial. The debate focuses mainly on the precise role of hormonal medical treatment and surgery and on the most suitable surgical technique to be used. In particular, considering the risks of second-line surgery, prevention of recurrences after first-line surgery is a priority in this context. Post-surgical medical therapy has been advocated to improve the effectiveness of surgery and prevent recurrences. However, adjuvant therapy, i.e. a short course of 3-6 months of hormonal therapy after surgery, has been proven to be of limited or no benefit for endometriosis in general and for deep peritoneal endometriosis in particular. On the other hand, two cohort studies suggest a beneficial effect of prolonged hormonal therapy after surgery for deep endometriosis. Even if this evidence is too weak to confidently advocate systematic administration of prolonged medical therapy after surgery, we argue in favour of this approach because of the strong association of deep endometriosis with other disease forms. In fact, women operated on for deep endometriosis may also face recurrences of endometriomas, superficial peritoneal lesions and pelvic pain in general. The demonstrated high effectiveness of prolonged postoperative therapy for the prevention of endometriomas' formation and dysmenorrhea recurrence should thus receive utmost consideration in the decision-making process.

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Condition tags

endometriosis

MeSH descriptors

Contraceptives, Oral, Combined Endometriosis Peritoneal Diseases Contraceptives, Oral, Combined Endometriosis Endometriosis Endometriosis Female Humans Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Postoperative Care Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (57)

Cited by (24)

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