POSSIBILITIES OF THERAPY OF PAIN SYNDROME IN ENDOMETRIOSIS

Yu. A. DUBOSSARSKAYA, Z. M. Dubossarskaya, Л.П. Грек
In: Scientific digest of association of obstetricians and gynecologists of Ukraine · 2021 · pp. 23–29 · doi:10.35278/2664-0767.1(47).2021.242670 · W3215777110
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study developed a treatment and rehabilitation approach for endometriosis patients, finding it reduced pelvic pain, improved psycho-emotional state, and normalized sleep in the majority of participants.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper aimed to pathogenetically justify treatment and rehabilitation measures for women with genital endometriosis accompanied by pelvic pain, using immunohistochemical markers of endometriosis-related biology (ER, PGR, Ki-67, VEGF, COX-2 in eutopic endometrium) alongside psychological characteristics and pain intensity to select a therapeutic strategy. The study evaluated 85 patients with severe (VAS 7–10) and moderate (VAS 4–6) pelvic pain, reporting that the proposed approach shifted pain toward mild levels over both short- and long-term follow-up (p < 0.05). It also found reductions in personal anxiety at 6 and 12 months and decreased depressive symptoms on the Hamilton scale across the study groups. The paper does not explicitly state key limitations such as whether there was a control group or how treatments were standardized beyond marker-informed selection, and this uncertainty affects the strength of causal interpretation. This paper is centrally about endometriosis — it focuses on therapy of the pain syndrome in women with genital endometriosis, integrating immunohistochemical and psychosocial parameters to guide treatment and report pain and mental health outcomes.

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Abstract

Therapeutic tactics of endometriosis are aimed primarily at overcoming the pain syndrome, the absence of recurrence of the underlying disease, maintaining fertility and improving the psycho-emotional state of women. The objective to develop, pathogenetically substantiate treatment and rehabilitation measures taking into account pathogenetic preconditions in women with endometriosis in combination with pain. Materials and methods 85 patients with genital endometriosis with severe pelvic pain (VAS 7-10 points) (n = 44) - group I and moderate (VAS 4-6 points) (n = 41) - group II. The mean age of women in clinical trials I and II of the study was 37.71 ± 0.93 and 41.05 ± 1.08 (M ± m) years, respectively. The choice of treatment tactics was determined on the basis of immunohistochemical markers: estrogen receptors (ER), progesterone (PGR), proliferation index (Ki-67), vasculoendothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) in eutopic acid., psychoemotional characteristics and intensity of pelvic pain. Rеsultes of treatment in the examined patients a significant (p <0.05) reduction of pelvic pain was determined, both in the short and long term. After 6 months, the level of personal anxiety decreased - by - 38.62%, after 12 months. – at - 48.15% (p <0.05). The rate of decrease in the level of depressive disorders on the Hamilton scale of all studied women was: - 32.2% after 6 months and -42.15% after 12 months (p <0.05). Conclusion our approach to treating endometriosis helped to overcome pain in 83.53% of women, improve psycho-emotional and general condition, normalize sleep - was determined in 88.3% of women, reduce reactive anxiety and depressive disorders in 84.7% of patients, indicates the effectiveness proposed therapy.

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Outcome instruments

VAS-pain

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

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