The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model

Tuncer Çaycı, Tuncer Cayci, Emin Özgür Akgül, Emin Ozgur Akgul, Yasemin Gulcan Kurt, Yasemin Gülcan Kurt, Temel Ceyhan, Temel S Ceyhan, Ibrahim Aydin, İbrahim Aydın, Onder Onguru, Önder Öngürü, Halil Yaman, Halıl Yaman, Erdinç Çakır, Erdinc Cakir, Mehmet Yasar, Mehmet Yaşar, Cumhur Bilgi, Kemal M Erbil, Kemal Erbil
Journal of Obstetrics and Gynaecology Research · 2011 · vol. 37(8) , pp. 1041–1047 · doi:10.1111/j.1447-0756.2010.01482.x · PMID:21481092 · W1895322793
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Infliximab, etanercept, and letrozole treatments in a rat endometriosis model reduced implant size while increasing plasma ADMA and decreasing plasma nitrate/nitrite levels.

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Abstract

AIM: To investigate the levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) in all the rat endometriosis models. MATERIAL & METHODS: Forty-one rats with endometriotic implants were divided into four groups (1 to 4) and administered infliximab, etanercept, letrozole and control, respectively. There were 11 rats in group 5 (normal). The size of implants, plasma ADMA and nitrate/nitrite (NO(x) ) levels and histological score were assessed. RESULTS: In groups 1, 2 and 3, plasma ADMA levels were higher than groups 4 and 5, 296.8 ± 66.2, 285.9 ± 35.7, 200.3 ± 41.0, 125.3 ± 16.7, 111.3 ± 6.5 µmol/L, respectively, while NO(x) levels were lower than groups of control and normal 19.6 ± 3.8, 19.8 ± 4.4, 39.3 ± 6.1, 80.5 ± 5.3, and 91.1 ± 5.0 µmol/L, respectively. CONCLUSIONS: Infliximab, etanercept and letrozole have regressed endometriotic implants, decreased plasma NO(x) levels, and increased plasma ADMA levels.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Arginine Endometriosis Nitric Oxide Peritoneal Diseases Animals Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Arginine Arginine Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Nitric Oxide Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Random Allocation Rats

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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