The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model

Tuncer Çaycı, Tuncer Cayci, Cayci T, Emin Ozgur Akgul, Akgul EO, Emin Özgür Akgül, Yasemin Gülcan Kurt, Kurt YG, Yasemin Gulcan Kurt, Temel Ceyhan, Temel S Ceyhan, Ceyhan TS, Aydin I, İbrahim Aydın, Ibrahim Aydin, Önder Öngürü, Onder Onguru, Onguru O, Halil Yaman, Halıl Yaman, Yaman H, Cakir E, Erdinc Cakir, Erdinç Çakır, Mehmet Yaşar, Mehmet Yasar, Yasar M, Bilgi C, Cumhur Bilgi, Kemal M Erbil, Kemal Erbil, Erbil KM
Journal of Obstetrics and Gynaecology Research · 2011 · vol. 37(8) , pp. 1041–1047 · doi:10.1111/j.1447-0756.2010.01482.x · PMID:21481092 · W1895322793
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Infliximab, etanercept, and letrozole treatments in a rat endometriosis model reduced implant size while increasing plasma ADMA and decreasing plasma nitrate/nitrite levels.

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Abstract

AIM: To investigate the levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) in all the rat endometriosis models. MATERIAL & METHODS: Forty-one rats with endometriotic implants were divided into four groups (1 to 4) and administered infliximab, etanercept, letrozole and control, respectively. There were 11 rats in group 5 (normal). The size of implants, plasma ADMA and nitrate/nitrite (NO(x) ) levels and histological score were assessed. RESULTS: In groups 1, 2 and 3, plasma ADMA levels were higher than groups 4 and 5, 296.8 ± 66.2, 285.9 ± 35.7, 200.3 ± 41.0, 125.3 ± 16.7, 111.3 ± 6.5 µmol/L, respectively, while NO(x) levels were lower than groups of control and normal 19.6 ± 3.8, 19.8 ± 4.4, 39.3 ± 6.1, 80.5 ± 5.3, and 91.1 ± 5.0 µmol/L, respectively. CONCLUSIONS: Infliximab, etanercept and letrozole have regressed endometriotic implants, decreased plasma NO(x) levels, and increased plasma ADMA levels.

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Condition tags

endometriosis

MeSH descriptors

Arginine Endometriosis Nitric Oxide Peritoneal Diseases Animals Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Arginine Arginine Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Nitric Oxide Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Random Allocation Rats

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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