Secondary müllerian system and endometriosis

Fujii S, S Fujii, Shingo Fujii
American journal of obstetrics and gynecology · 1991 · vol. 165(1) , pp. 219–225 · doi:10.1016/0002-9378(91)90255-p · PMID:1853900 · W1984257375
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper investigates the secondary Müllerian system and its connection to endometriosis, exploring potential roles and mechanisms.

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Abstract

The pathogenesis of endometriosis is controversial. The two principal histogenetic theories are (1) metastases of endometrial tissues to an ectopic location (metastatic theory) and (2) metaplastic development of endometrial tissue at the ectopic site (metaplastic theory). Studies on the development of the coelomic cavity and the müllerian duct, as well as expression of CA 125 during the fetal period and in the adult, strongly suggest that coelomic epithelium-related tissues and müllerian-derived epithelia of the adult have a shared embryologic ancestry. Many manifestations of müllerian-directed metaplasia suggest that tissues derived from the coelomic epithelium and its accompanying mesenchymal cells, referred to as the "secondary müllerian system," have the potentiality to differentiate into müllerian-directed epithelium and stroma. This metaplastic potentiality of the secondary müllerian system constitutes a basic concept in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Mullerian Ducts Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Embryo, Mammalian Embryo, Mammalian Endometriosis Endometriosis Female Genital Diseases, Female Genital Diseases, Female Genitalia, Female Genitalia, Female Humans Mullerian Ducts

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (58)

Cited by (50)

Source provenance

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License: CC0 · commercial use OK