Umit A. Kayisli

ORCID: 0000-0002-0379-2168 · 40 papers in corpus · active 2002-2024

Study types

  • article 30
  • other 6
  • book-chapter 2
  • review 2

Condition tags

  • endometriosis 29
  • adenomyosis 6
  • infertility 1
other 2024
Dysregulated expression of GATA2 and GATA6 transcription factors in adenomyosis: implications for impaired endometrial receptivity
F&S science ·doi:10.1016/j.xfss.2023.11.003

OBJECTIVE: To study the effect of adenomyosis on the localized expression of the GATA binding proteins 2 and 6 (GATA2 and GATA6) zinc-finger transcription factors that are involved in proliferation of hematopoietic and endocrine cell lineag…

article 2023
IN-VITRO GATA2 OVEREXPRESSION REVERSES DECIDUALIZATION DEFECTS BY IMPROVING ENDOMETRIAL RECEPTIVITY MARKERS IN HUMAN ENDOMETRIAL STROMAL CELLS FROM PATIENTS WITH ADENOMYOSIS
·doi:10.1016/j.fertnstert.2023.08.489
article 2022
DYSREGULATED GATA2 AND GATA6 TRANSCRIPTION FACTOR EXPRESSION IN PATIENTS WITH ADENOMYOSIS: IMPLICATIONS FOR IMPAIRED ENDOMETRIAL RECEPTIVITY
·doi:10.1016/j.fertnstert.2022.08.581
article 2020
Catecholestradiol Activation of Adrenergic Receptors Induces Endometrial Cell Survival via p38 MAPK Signaling
The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgaa866

CONTEXT: Enhanced levels of catecholestradiols, 2-hydroxyestradiol (2-OHE2) or 4-hydroxyestradiol (4-OHE2), are reported in endometriosis. During gestation, catecholestradiol activation of adrenergic receptors (AR) elevates estrogen recepto…

article 2020
The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.09.012
article 2019
GATA binding protein 2 expression at implantation window diminishes in women with adenomyosis: implications for impaired endometrial receptivity
·doi:10.1016/j.fertnstert.2019.07.956
article 2019
Propranolol inhibits catecholestrogen-induced human endometrial stromal cell survival mediated by p38 MAPK signaling: potential therapy for endometriosis
·doi:10.1016/j.fertnstert.2019.07.943
article 2019
α1D-adrenergic receptor expression in human endometrial stromal cells contributes to catecholestradiol-induced cell survival: implications for endometriosis
·doi:10.1016/j.fertnstert.2019.07.946
article 2019
β2-Adrenergic receptor expression in human endometrial endothelial cells potentially mediates 2-hydroxyestradiol-induced microvascular stabilization: implications for endometriosis
·doi:10.1016/j.fertnstert.2019.02.056
other 2018
Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells
Turkish journal of obstetrics and gynecology ·doi:10.4274/tjod.47700

OBJECTIVE: When bound to the inhibitory kappa B (IкB) protein, the transcription factor nuclear factor kappa B (NF-кB) remains inactively in the cytoplasm. Activated NF-кB upregulates the gene expression of many chemokines including monocyt…

article 2017
In vivo effects of curcumin and deferoxamine in experimental endometriosis
Advances in clinical and experimental medicine : official organ Wroclaw Medical University ·doi:10.17219/acem/31186

BACKGROUND: Endometriosis is one of the most common chronic gynecological diseases. OBJECTIVES: The aim of the study was to examine the effects of curcumin and/or deferoxamine on cell proliferation in a rat model of endometriosis. MATERIAL …

article 2017
p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719117725828
article 2017
The extracellular signal‐regulated kinase 1/2 triggers angiogenesis in human ectopic endometrial implants by inducing angioblast differentiation and proliferation
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12760

PROBLEM: The role of extracellular signal-regulated kinase (ERK)1/2-mediated angiogenesis during endometriotic nidation is unknown. We posit that ERK1/2-induced angioblast differentiation and proliferation promotes ectopic endometrial angio…

article 2016
Decreased Endometrial Expression of Leukemia Inhibitory Factor Receptor Disrupts the STAT3 Signaling in Adenomyosis During the Implantation Window
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719116681515
review 2016
The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding
Human reproduction update ·doi:10.1093/humupd/dmw004

BACKGROUND: Human pregnancy requires robust hemostasis to prevent hemorrhage during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification of spiral arteries and post-partum processes. However, decidual hemorr…

other 2011
The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719110382307

Cytokines modulate turnover of the endometrium during the menstrual cycle and contribute to the pathogenesis of endometriosis. Gene expression for cytokines is often regulated by proteins that bind to adenosine- and uridine-rich elements (A…

article 2010
Bidirectional regulation of unfolding protein response in human endometrium and endometriosis
·doi:10.1016/j.fertnstert.2010.07.837
book-chapter 2010
Endometriosis is an Inflammatory Disease
·doi:10.4324/9780203319390_chapter_6
article 2010
HOXA10 expression is decreased in endometrium of women with adenomyosis
·doi:10.1016/j.fertnstert.2010.07.693
article 2010
Increased c-Jun N-terminal kinase activation in human endometriotic endothelial cells
Histochemistry and cell biology ·doi:10.1007/s00418-010-0770-2
other 2010
Regulation of monocyte chemotactic protein-1 expression in human endometrial endothelial cells by sex steroids: a potential mechanism for leukocyte recruitment in endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719109352380

The main aim of this study is to describe the in vivo temporal and spatial expression of monocyte chemotactic protein 1 (MCP-1) in human endometrial endothelial cells (HEECs) and to compare the in vitro regulation of MCP-1 expression by sex…

article 2009
Differential regulation of Akt phosphorylation in endometriosis
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2009.10.001
other 2008
DNA-binding ability of NF-kappaB is affected differently by ERalpha and ERbeta and its activation results in inhibition of estrogen responsiveness
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719108317583

Estrogenic effects involve interactions between estrogen receptors (ERs), response elements, and nuclear proteins. It is hypothesized that interaction between ER and NF-kappa B may affect the regulation of responsive genes. Electrophoretic …

article 2008
Extracellularly Signal-Regulated Kinase Activity in the Human Endometrium: Possible Roles in the Pathogenesis of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2007-2051

CONTEXT: Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic pain and infertility in 10% of reproductive-aged women. It is unclear why ectopic endo…

article 2007
The Broad-Spectrum Chemokine Inhibitor NR58-3.14.3 Suppresses the Implantation and Survival of Human Endometrial Implants in the Nude Mice Endometriosis Model
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719107305865