Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8

Naciye Mülayim, Mulayim N, Naciye Mulayim, Asim Savlu, Savlu A, Ozlem Guzeloglu‐Kayisli, Guzeloglu-Kayisli O, Ozlem Guzeloglu-Kayisli, Umit A. Kayisli, Kayisli UA, Aydın Arıcı, Aydin Arici, Arici A
Fertility and sterility · 2004 · vol. 81 , pp. 904–911 · doi:10.1016/j.fertnstert.2003.11.015 · PMID:15019828 · W2007059239
Lab / animal OA: bronze CC0 ⤵ 49 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Interleukin-8 influences endometrial stromal cell matrix metalloproteinase activity and invasiveness.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate the effect of interleukin-8 (IL-8) on endometrial stromal cell metalloproteinase (MMP) activity and invasiveness. DESIGN: Experimental laboratory study. SETTING: University medical center. PATIENT(S): Reproductive age women without endometriosis. INTERVENTION(S): Endometrial stromal cells were grown in culture and treated with recombinant IL-8 (0.0001-10 ng/mL) for 24 to 48 hours. Supernatants were collected for soluble assay of collagenase activity and gelatin zymography. Endometrial stromal cells were plated on 8-microm pore membranes coated with Matrigel or human simple matrix and treated with IL-8 for 48 hours. MAIN OUTCOME MEASURE(S): Collagenase activity and MMP2 and 9 activity of control vs. IL-8 treated endometrial cells, and number of endometrial cells that invade through Matrigel or human simple matrix. RESULT(S): Collagenase activity in cells treated with IL-8 (1-10 ng/mL) was higher than in control cells. On gelatin zymograms, MMP2 and MMP9 activity of endometrial stromal cells was stimulated by IL-8 treatment (1-10 ng/mL). The number of cells that invaded the Matrigel or human simple matrix was 1.7-fold higher in the group treated with 10 ng/mL of IL-8 compared with the control group. CONCLUSION(S): IL-8 increases MMP activity and invasive capability of endometrial stromal cells in culture; IL-8 may be involved in the pathogenesis of endometriosis and menstrual physiology.

My notes (saved in your browser only)

MeSH descriptors

Endometrium Interleukin-8 Matrix Metalloproteinase 9 Stromal Cells Adult Adult Biocompatible Materials Biocompatible Materials Cell Movement Cell Movement Cell Movement Cells, Cultured Cells, Cultured Collagen Collagen Collagenases Collagenases Collagenases Collagenases Drug Combinations

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (59)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-12T06:17:10.165071+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:02:29.018211+00:00
License: CC0 · commercial use OK