The endometrial microbiota and its influence on the development of endometrial cancer: Resolving controversies and elucidating the mechanisms

Yuan Gong, Xiang Huang, Yani Ding, Fang Gou, Feifei Gou, Weijie Tian, Dan Zi
In: Journal of Reproductive Immunology · 2025 · vol. 172 , pp. 104745 · doi:10.1016/j.jri.2025.104745 · PMID:41172772 · W4415531722
review OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-21 ⓘ

This paper reviews the current understanding of the endometrial microbiota's role in endometrial cancer development, aiming to resolve existing controversies and clarify the underlying mechanisms.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

High-throughput sequencing reveals that organs once considered sterile, such as the endometrium, actually harbor distinct microbial communities. These organ-specific microbiota play critical roles in disease pathogenesis, including cancer. Nevertheless, defining a healthy endometrial microbiota remains challenging due to inconsistent compositional profiles reported across studies. Furthermore, although endometrial dysbiosis has been linked to endometrial cancer (EC), multiple confounding factors influence specific microbial signatures, and the causal relationship between these microbes and EC pathogenesis remains a topic of debate. This review aims to systematically examine current research on the endometrial microbiota, analyze the factors contributing to discrepancies in study findings, and elucidate the potential interaction mechanisms between the endometrial microbiota and EC.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-08-19T06:23:00.919175+00:00
License: CC0 · commercial use OK