Combination of estrogen and dioxin is involved in the pathogenesis of endometriosis by promoting chemokine secretion and invasion of endometrial stromal cells

Jing Yu, J. Yu, Yun Wang, Yu Wang, Wen-Hui Zhou, Wen‐Jie Zhou, Ling Wang, Yangyang He, Yin-Yan He, D.-J. Li, Da-Jin Li
Human Reproduction · 2008 · vol. 23(7) , pp. 1614–1626 · doi:10.1093/humrep/den125 · PMID:18456672 · W2108649673
article OA: bronze CC0 ⤵ 44 in-corpus citations
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Estrogen and dioxin together increased secretion of RANTES and MIP-1alpha, promoting endometrial stromal cell invasion by upregulating MMP-2 and MMP-9.

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Abstract

BACKGROUND: The CC chemokines, regulated on activation, normal T-cell expressed and secreted (RANTES) and macrophage-inflammatory protein-1alpha (MIP-1alpha), have been identified as potential contributors to the pathogenesis and the progression of endometriosis. Dioxin, an air pollutant, and estrogen also appear to be involved in endometriosis. The aim of this study was to probe into the effect of dioxin and estrogen on expression of the chemokines in endometriosis-associated cells, and to explore the pathogenesis of endometriosis. METHODS: Co-culture models were established to evaluate the secretion of human RANTES and MIP-1alpha. The effects of a dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and estrogen on the invasion of endometrial stromal cells (ESC) were also examined by using an invasion assay, and the translation and proteolytic activity of matrix metalloproteinase (MMP)-9 and MMP-2 in ESC were determined by western blot and zymography, respectively. RESULTS: Our results showed that the combination of 17beta-estradiol and TCDD increased the secretion of RANTES and MIP-1alpha, promoted the invasiveness of ESC and increased the expression of MMP-2 and MMP-9 in ESC. Anti-RANTES, anti-MIP-1alpha neutralizing antibody or antibody against their receptors could effectively inhibit the invasiveness of ESC and the expression of MMP-2 and MMP-9. CONCLUSIONS: The combination of 17beta-estradiol with TCDD may facilitate the onset of endometriosis and contribute to its development by increasing the invasion of ESC mediated by CC-motif chemokines.

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Condition tags

endometriosis

MeSH descriptors

Chemokine CCL3 Chemokine CCL5 Endometriosis Estradiol Polychlorinated Dibenzodioxins Stromal Cells Adult Cell Line Chemokine CCL3 Chemokine CCL5 Coculture Techniques Endometriosis Endometrium Endometrium Estradiol Female Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 2 Matrix Metalloproteinase 9

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