Non-endometrioid Synchronized Endometrial and Ovarian Carcinoma: Report of Two Rare Cases

Soheila Aminimoghaddam, Elham Saffarieh, Pegah Kamkarfar, Mahsa Kiani, Parinaz Hamednasimi
In: International Journal of Women's Health and Reproduction Sciences · 2023 · vol. 12(4) , pp. 190–194 · doi:10.15296/ijwhr.2023.8010 · W4407144426
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This report details two rare non-endometrioid synchronized endometrial and ovarian carcinoma cases, one low-grade papillary serous and the other clear cell carcinoma with endometrioid adenocarcinoma, suggesting chemotherapy may not benefit low-grade tumors and targeted therapy might be better for high-grade ones.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This paper reports two rare cases of synchronized endometrial and ovarian carcinoma (SEOC), specifically non-endometrioid tumor combinations: one with low-grade papillary serous carcinoma involving both the ovary and uterine endometrium, and another with clear cell carcinoma in the ovary alongside endometrioid adenocarcinoma in the uterus. Across the case descriptions and a brief literature review, the authors note that SEOC tumors are often diagnosed at early stages and can show better prognosis than metastatic disease, and they discuss diagnostic differentiation as essential. They conclude that routine adjuvant chemotherapy may not be helpful for early-stage low-grade tumors, while high-grade tumors may involve genetic mutations that could support targeted therapy after surgery, with the limitation that this is based on rare case material and literature synthesis rather than systematic data. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Objectives: Synchronized endometrial and ovarian cancer (SEOC) is a condition in which there is both primary endometrial and primary ovarian cancer at the same time in a patient. These tumors have a better prognosis than metastatic ones. Most of them are diagnosed in the early stages and are low-grade tumors. So differentiation of this kind of rare tumor from others is essential. No adjuvant chemotherapy seems to be reasonable in cases with low-grade tumors both in endometrioid and non-endometrioid types. High-grades tumors have been described less, but, in some studies, genetic mutations were found in these tumors, which have been the basis of targeted therapy after surgery. Case Presentation: In this report, two rare non-endometrioid types of SEOC cases are discussed. The first case is a low-grade papillary serous carcinoma of the ovary and uterus endometrium. In contrast, the second case is a clear cell carcinoma of the ovary and endometrioid adenocarcinoma of the uterus. We also review the literature in this field. Conclusion: We conclude that in these cases, chemotherapy with routine regimens does not seem to be helpful in early stages with low-grade tumors. Also, in high-grade tumors, targeted therapy may be more effective than adjuvant chemotherapy.
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Oct 2024, Vol 12, Issue 4 Advanced Search For Author's & Reviewer's Poll How do you find the scientific quality of the published articles on our web site? | Case Report | | | Non-endometrioid Synchronized Endometrial and Ovarian Carcinoma: Report of Two Rare Cases | | | Soheila Aminimoghaddam1, Elham Saffarieh2, Pegah Kamkarfar3, Mahsa Kiani3, Parinaz Hamednasimi3 | | | 1Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran 2Abnormal Uterine Bleeding Center of Semnan University of Medical Sciences, Semnan, Iran 3Endometriosis Research Centers of Iran University of Medical Sciences, Tehran, Iran | | | IJWHR 2024; 12: 190-194 DOI: 10.15296/ijwhr.2023.8010 Viewed : 2167 times Downloaded : 2478 times. Keywords : Papillary serous carcinoma, Clear cell carcinoma, synchronized endometrial, Ovarian cancer | | | Full Text(PDF) | Related Articles | | | Abstract | | Objectives: Synchronized endometrial and ovarian cancer (SEOC) is a condition in which there is both primary endometrial and primary ovarian cancer at the same time in a patient. These tumors have a better prognosis than metastatic ones. Most of them are diagnosed in the early stages and are low-grade tumors. So differentiation of this kind of rare tumor from others is essential. No adjuvant chemotherapy seems to be reasonable in cases with low-grade tumors both in endometrioid and non-endometrioid types. High-grades tumors have been described less, but, in some studies, genetic mutations were found in these tumors, which have been the basis of targeted therapy after surgery. Case Presentation: In this report, two rare non-endometrioid types of SEOC cases are discussed. The first case is a low-grade papillary serous carcinoma of the ovary and uterus endometrium. In contrast, the second case is a clear cell carcinoma of the ovary and endometrioid adenocarcinoma of the uterus. We also review the literature in this field. Conclusion: We conclude that in these cases, chemotherapy with routine regimens does not seem to be helpful in early stages with low-grade tumors. Also, in high-grade tumors, targeted therapy may be more effective than adjuvant chemotherapy. | Cite By, Google Scholar Articles by Aminimoghaddam S Articles by Saffarieh E Articles by Kamkarfar P Articles by Kiani M Articles by Hamednasimi P Articles by Soheila Aminimoghaddam Articles by Elham Saffarieh Articles by Pegah Kamkarfar Articles by Mahsa Kiani Articles by Parinaz Hamednasimi Submit Paper Online Submission System IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal Online Submission System IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal Publication Information Publisher Aras Part Medical International Press Editor-in-Chief Arash Khaki Mertihan Kurdoglu Deputy Editor Zafer Akan Aras Part Medical International Press Editor-in-Chief Arash Khaki Mertihan Kurdoglu Deputy Editor Zafer Akan Published Article Statistics

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