The deviations of CD4 + T cells during peripheral blood and peritoneal fluid of endometriosis: a systematic review and meta-analysis

Hua Yang; Yuan Zhuang

doi:10.1007/s00404-023-06964-3

The deviations of CD4 + T cells during peripheral blood and peritoneal fluid of endometriosis: a systematic review and meta-analysis

Hua Yang, Yuan Zhuang

Archives of gynecology and obstetrics · 2023 · vol. 308(5) , pp. 1431–1446 · doi:10.1007/s00404-023-06964-3 · PMID:36840769 · W4321850418

review OA: closed CC0 ⤵ 5 in-corpus citations

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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This systematic review and meta-analysis found no significant deviations of CD4+ T cells in peripheral blood of endometriosis patients, but did find significant local deviations in peritoneal fluid.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid

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References (58)

Alteration of systemic and uterine endometrial immune populations in patients with endometriosis via openalex
Alterations of CD4+T Cell Subsets in Blood and Peritoneal Fluid in Different Stages of Endometriosis. via openalex
Anti-inflammatory cytokines in endometriosis via openalex
Bacterial contamination hypothesis: a new concept in endometriosis via openalex
Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing via openalex
Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review via openalex
Changes of peripheral blood lymphocyte subsets before and after operation of patients with endometriosis via openalex
Characterization of Peripheral Blood and Peritoneal Fluid Mononuclear Cell Subsets in Fertile and Infertile Women via openalex
Clinical, morphological and immunohistochemical survey in different types of endometriosis. via openalex
Cytolysis of Eutopic and Ectopic Endometrial Cells by Peripheral Blood Monocytes and Peritoneal Macrophages in Women with Endometriosis via openalex
Deficient cellular immunity in endometriosis via openalex
Different concentrations of interleukins in the peritoneal fluid of women with endometriosis: relationships with lymphocyte subsets via openalex
Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis via openalex
Endometrial stem/progenitor cells and their roles in immunity, clinical application, and endometriosis via openalex
Endometriosis via openalex
Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment via openalex
Endometriosis and cardiovascular disease via openalex
Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications via openalex
Endometriosis: Effect of endometriosis on white blood cell subpopulations in peripheral blood and peritoneal fluid of baboons via openalex
Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons via openalex
Endometriosis: What is the Influence of Immune Cells? via openalex
Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity via openalex
Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction via openalex
Extrapelvic Endometriosis: A Systematic Review via openalex
Human Peritoneal Macrophage and T Lymphocyte Populations in Mild and Severe Endometriosis via openalex
Identification and Validation of the Signatures of Infiltrating Immune Cells in the Eutopic Endometrium Endometria of Women With Endometriosis via openalex
Immunopathogenesis of endometriosis – a novel look at an old problem via openalex
Immunosuppressive activity of peritoneal fluid in women with endometriosis. via openalex
Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate via openalex
Intraperitoneal immune cell status in infertile women with and without endometriosis via openalex
Involvement of immune cells in the pathogenesis of endometriosis via openalex
Killer Immunoglobulin‐like Receptor and Human Leukocyte Antigen Expression as Immunodiagnostic Parameters for Pelvic Endometriosis via openalex
Macrophages inhibit and enhance endometriosis depending on their origin via openalex
Pathogenesis of endometriosis: Look no further than John Sampson via openalex
Pathogenesis of endometriosis: the genetic/epigenetic theory via openalex
Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms via openalex
Peritoneal Fluid from Patients with Ovarian Endometriosis Displays Immunosuppressive Potential and Stimulates Th2 Response via openalex
Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis via openalex
Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity via openalex
Stem Cells in Endometrium and Endometriosis via openalex
The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis via openalex
The Lymphatic System in Endometriosis: a Pilot Study of Endometrial-Like Cells and Immune Cell Populations in Lymph Nodes Associated with Deep Infiltrating Bowel Lesions via openalex
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex
The role of cell-mediated immunity in pathogenesis of endometriosis. via openalex
The Role of Peritoneal Macrophages in Endometriosis via openalex
The role of the B lymphocytes in endometriosis: A systematic review via openalex
W1981403557 via openalex
W1681346990 via openalex
W141728048 via openalex
W2884952568 via openalex
W10086957 via openalex
W2624434883 via openalex
W2166025830 via openalex
W3119380823 via openalex
W2126930838 via openalex
W3141256924 via openalex
W2096030110 via openalex
W2049345643 via openalex

Cited by (5)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-06-04T00:34:07.146298+00:00

License: CC0 · commercial use OK

[1] Alteration of systemic and uterine endometrial immune populations in patients with endometriosis via openalex

[2] Alterations of CD4+T Cell Subsets in Blood and Peritoneal Fluid in Different Stages of Endometriosis. via openalex

[3] Anti-inflammatory cytokines in endometriosis via openalex

[4] Bacterial contamination hypothesis: a new concept in endometriosis via openalex

[5] Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing via openalex

[6] Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review via openalex

[7] Changes of peripheral blood lymphocyte subsets before and after operation of patients with endometriosis via openalex

[8] Characterization of Peripheral Blood and Peritoneal Fluid Mononuclear Cell Subsets in Fertile and Infertile Women via openalex

[9] Clinical, morphological and immunohistochemical survey in different types of endometriosis. via openalex

[10] Cytolysis of Eutopic and Ectopic Endometrial Cells by Peripheral Blood Monocytes and Peritoneal Macrophages in Women with Endometriosis via openalex

[11] Deficient cellular immunity in endometriosis via openalex

[12] Different concentrations of interleukins in the peritoneal fluid of women with endometriosis: relationships with lymphocyte subsets via openalex

[13] Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis via openalex

[14] Endometrial stem/progenitor cells and their roles in immunity, clinical application, and endometriosis via openalex

[15] Endometriosis via openalex

[16] Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment via openalex

[17] Endometriosis and cardiovascular disease via openalex

[18] Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications via openalex

[19] Endometriosis: Effect of endometriosis on white blood cell subpopulations in peripheral blood and peritoneal fluid of baboons via openalex

[20] Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons via openalex

[21] Endometriosis: What is the Influence of Immune Cells? via openalex

[22] Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity via openalex

[23] Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction via openalex

[24] Extrapelvic Endometriosis: A Systematic Review via openalex

[25] Human Peritoneal Macrophage and T Lymphocyte Populations in Mild and Severe Endometriosis via openalex

[26] Identification and Validation of the Signatures of Infiltrating Immune Cells in the Eutopic Endometrium Endometria of Women With Endometriosis via openalex

[27] Immunopathogenesis of endometriosis – a novel look at an old problem via openalex

[28] Immunosuppressive activity of peritoneal fluid in women with endometriosis. via openalex

[29] Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate via openalex

[30] Intraperitoneal immune cell status in infertile women with and without endometriosis via openalex

[31] Involvement of immune cells in the pathogenesis of endometriosis via openalex

[32] Killer Immunoglobulin‐like Receptor and Human Leukocyte Antigen Expression as Immunodiagnostic Parameters for Pelvic Endometriosis via openalex

[33] Macrophages inhibit and enhance endometriosis depending on their origin via openalex

[34] Pathogenesis of endometriosis: Look no further than John Sampson via openalex

[35] Pathogenesis of endometriosis: the genetic/epigenetic theory via openalex

[36] Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms via openalex

[37] Peritoneal Fluid from Patients with Ovarian Endometriosis Displays Immunosuppressive Potential and Stimulates Th2 Response via openalex

[38] Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis via openalex

[39] Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity via openalex

[40] Stem Cells in Endometrium and Endometriosis via openalex

[41] The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis via openalex

[42] The Lymphatic System in Endometriosis: a Pilot Study of Endometrial-Like Cells and Immune Cell Populations in Lymph Nodes Associated with Deep Infiltrating Bowel Lesions via openalex

[43] The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex

[44] The role of cell-mediated immunity in pathogenesis of endometriosis. via openalex

[45] The Role of Peritoneal Macrophages in Endometriosis via openalex

[46] The role of the B lymphocytes in endometriosis: A systematic review via openalex

[47] W1981403557 via openalex

[48] W1681346990 via openalex

[49] W141728048 via openalex

[50] W2884952568 via openalex

[51] W10086957 via openalex

[52] W2624434883 via openalex

[53] W2166025830 via openalex

[54] W3119380823 via openalex

[55] W2126930838 via openalex

[56] W3141256924 via openalex

[57] W2096030110 via openalex

[58] W2049345643 via openalex