Role of Natural Killer Cell Activity in the Pathogenesis of Endometriosis

Keywords: Cytokines, endometriosis, NK cells, peritoneal fluid, Natural Killer, major his-tocompatibility complex (MHC), innate immunity, granular lymphocytes, histocompati-bility complex, hematopoietic stem cells, perforins, gran-zymes, immuno-globulin class G (IgG), interferon (IFN), chemoattractant protein 1, immunoglobulin, immunoregulatory, endometrium, dysmenorrhea, ectopic sites, gonadotropin-releasing hormone agonist (GnRH), laparoscopic surgery, polymorphism, matrix metalloproteinase, IFN-gene, danazol, paclitaxel, carboplatin, 5-fluorouraci, malignant melanoma, immunomodulatory activ-ity, mycobacterium vaccination, endometrioid heterotopies Current Medicinal Chemistry Title: Role of Natural Killer Cell Activity in the Pathogenesis of Endometriosis Volume: 18 Issue: 2 Author(s): Justyna Sikora, Aleksandra Mielczarek-Palacz and Zdzislawa Kondera-Anasz Affiliation:

Cytokines, endometriosis, NK cells, peritoneal fluid, Natural Killer, major his-tocompatibility complex (MHC), innate immunity, granular lymphocytes, histocompati-bility complex, hematopoietic stem cells, perforins, gran-zymes, immuno-globulin class G (IgG), interferon (IFN), chemoattractant protein 1, immunoglobulin, immunoregulatory, endometrium, dysmenorrhea, ectopic sites, gonadotropin-releasing hormone agonist (GnRH), laparoscopic surgery, polymorphism, matrix metalloproteinase, IFN-gene, danazol, paclitaxel, carboplatin, 5-fluorouraci, malignant melanoma, immunomodulatory activ-ity, mycobacterium vaccination, endometrioid heterotopies

Natural Killer (NK) cells are cytotoxic effector lymphocytes with the ability to lyse target cells in a major histocompatibility complex (MHC) class I-independent manner and without the need for prior antigen exposure. Data strongly suggested that NK cells play an important role in human reproduction and disturbance in their function can favor development of the gynecological disorders. In our study the role of NK cells in pathogenesis of endometriosis is reviewed and summarized from available literature. Endometriosis is related to a defect of NK cell cytotoxicity function in the ability to eliminate endometrial cells in ectopic sites. Alternations of the innate immunity mediated by NK cells may promote impairments or disrupt functions of adaptive immunity, which can contribute to development and progression of endometriosis and infertility associated with endometriosis. Aberrant immune responses by NK cells in affected women may represent risk factors for endometriosis and the repaired function can be a new treatment target of the affected women. Export Options About this article Cite this article as: Sikora Justyna, Mielczarek-Palacz Aleksandra and Kondera-Anasz Zdzislawa, Role of Natural Killer Cell Activity in the Pathogenesis of Endometriosis, Current Medicinal Chemistry 2011; 18 (2) . https://dx.doi.org/10.2174/092986711794088416 | DOI https://dx.doi.org/10.2174/092986711794088416 | Print ISSN 0929-8673 | | Publisher Name Bentham Science Publishers | Online ISSN 1875-533X | Call for Papers in Thematic Issues Advance in Novel Drug and combined Therapies for Chronic Diseases Chronic diseases such as malignant tumors and rheumatoid arthritis have long plagued a large number of patients. Currently, the management of chronic diseases has entered a new stage of targeted regulation, precise intervention and integrated treatment. 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