{"paper_id":"087101b0-0c9f-41f5-8f72-58f71e1d1a8d","body_text":"Abstract\nKeywords: Cytokines, endometriosis, NK cells, peritoneal fluid, Natural Killer, major his-tocompatibility complex (MHC), innate immunity, granular lymphocytes, histocompati-bility complex, hematopoietic stem cells, perforins, gran-zymes, immuno-globulin class G (IgG), interferon (IFN), chemoattractant protein 1, immunoglobulin, immunoregulatory, endometrium, dysmenorrhea, ectopic sites, gonadotropin-releasing hormone agonist (GnRH), laparoscopic surgery, polymorphism, matrix metalloproteinase, IFN-gene, danazol, paclitaxel, carboplatin, 5-fluorouraci, malignant melanoma, immunomodulatory activ-ity, mycobacterium vaccination, endometrioid heterotopies\nCurrent Medicinal Chemistry\nTitle: Role of Natural Killer Cell Activity in the Pathogenesis of Endometriosis\nVolume: 18 Issue: 2\nAuthor(s): Justyna Sikora, Aleksandra Mielczarek-Palacz and Zdzislawa Kondera-Anasz\nAffiliation:\nKeywords: Cytokines, endometriosis, NK cells, peritoneal fluid, Natural Killer, major his-tocompatibility complex (MHC), innate immunity, granular lymphocytes, histocompati-bility complex, hematopoietic stem cells, perforins, gran-zymes, immuno-globulin class G (IgG), interferon (IFN), chemoattractant protein 1, immunoglobulin, immunoregulatory, endometrium, dysmenorrhea, ectopic sites, gonadotropin-releasing hormone agonist (GnRH), laparoscopic surgery, polymorphism, matrix metalloproteinase, IFN-gene, danazol, paclitaxel, carboplatin, 5-fluorouraci, malignant melanoma, immunomodulatory activ-ity, mycobacterium vaccination, endometrioid heterotopies\nAbstract: Natural Killer (NK) cells are cytotoxic effector lymphocytes with the ability to lyse target cells in a major histocompatibility complex (MHC) class I-independent manner and without the need for prior antigen exposure. Data strongly suggested that NK cells play an important role in human reproduction and disturbance in their function can favor development of the gynecological disorders. In our study the role of NK cells in pathogenesis of endometriosis is reviewed and summarized from available literature. Endometriosis is related to a defect of NK cell cytotoxicity function in the ability to eliminate endometrial cells in ectopic sites. Alternations of the innate immunity mediated by NK cells may promote impairments or disrupt functions of adaptive immunity, which can contribute to development and progression of endometriosis and infertility associated with endometriosis. Aberrant immune responses by NK cells in affected women may represent risk factors for endometriosis and the repaired function can be a new treatment target of the affected women.\nExport Options\nAbout this article\nCite this article as:\nSikora Justyna, Mielczarek-Palacz Aleksandra and Kondera-Anasz Zdzislawa, Role of Natural Killer Cell Activity in the Pathogenesis of Endometriosis, Current Medicinal Chemistry 2011; 18 (2) . https://dx.doi.org/10.2174/092986711794088416\n| DOI https://dx.doi.org/10.2174/092986711794088416 |\nPrint ISSN 0929-8673 |\n| Publisher Name Bentham Science Publishers |\nOnline ISSN 1875-533X |\nCall for Papers in Thematic Issues\nAdvance in Novel Drug and combined Therapies for Chronic Diseases\nChronic diseases such as malignant tumors and rheumatoid arthritis have long plagued a large number of patients. Currently, the management of chronic diseases has entered a new stage of targeted regulation, precise intervention and integrated treatment. The traditional diagnosis and treatment model is undergoing profound changes due to new drugs ...read more\nAdvances in Computational Strategies for Neurodegenerative Disorders, Cancer, and Infectious Diseases”\nThis thematic issue highlights recent advances in computational strategies applied to neurodegenerative disorders, cancer, and infectious diseases. It focuses on the use of artificial intelligence, machine learning, molecular modeling, molecular dynamics simulations, bioinformatics, and multi-omics data analysis to understand disease mechanisms and accelerate drug discovery. The contributions demonstrate how computational ...read more\nAI-Assisted Medicinal Chemistry and Bioactive Delivery Systems for Tissue Engineering and Regenerative Medicine\nThe proposed Mini-Thematic Issue aims to highlight recent advances at the interface of medicinal chemistry, artificial intelligence-assisted drug design, bioactive biomaterials, and regenerative medicine. With the rapid development of computational chemistry, quantitative structure–activity/structure–function relationship analysis, molecular docking, molecular dynamics simulation, high-throughput screening, and machine learning-based prediction models, medicinal chemistry is ...read more\nArtificial Intelligence Empowers the Research and Development of Anti-Infective Drugs: From Target Discovery and Molecular Design to Clinical Translation\nThe global crisis of drug resistance in bacteria, viruses, fungi, and parasites is becoming increasingly severe. Traditional anti-infective drug development faces bottlenecks such as long cycles, high costs, low success rates, and a shortage of novel structures. Artificial intelligence (AI) and machine learning are fundamentally reshaping the drug discovery and ...read more\n- Author Guidelines\n- Bentham Author Support Services (BASS)\n- Graphical Abstracts\n- Fabricating and Stating False Information\n- Research Misconduct\n- Post Publication Discussions and Corrections\n- Publishing Ethics and Rectitude\n- Increase Visibility of Your Article\n- Archiving Policies\n- Peer Review Workflow\n- Order Your Article Before Print\n- Promote Your Article\n- Manuscript Transfer Facility\n- Editorial Policies\n- Allegations from Whistleblowers\n- Announcements\nRelated Articles\nRecent Patents on Anti-Cancer Drug Discovery Microglia in Alzheimer's Disease: The Good, the Bad and the Ugly\nCurrent Alzheimer Research In Vivo Bio-imaging Using Chlorotoxin-based Conjugates\nCurrent Pharmaceutical Design Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy\nCurrent Medicinal Chemistry Sirtuins Family- Recent Development as a Drug Target for Aging, Metabolism, and Age Related Diseases\nCurrent Drug Targets Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer\nCurrent Cancer Drug Targets Physicochemical Properties that Determine Cellular Transport of Nanocarriers In Vitro and In Vivo\nCurrent Organic Chemistry H19/miR-675-5p Targeting SFN Enhances the Invasion and Metastasis of Nasalpharyngeal Cancer Cells\nCurrent Molecular Pharmacology TRIM45 Suppresses the Development of Non-small Cell Lung Cancer\nCurrent Molecular Medicine New Therapeutic Strategies for Cancer and Neurodegeneration Emerging from Yeast Cell-based Systems\nCurrent Pharmaceutical Design Review of 10,11-Dehydrocurvularin: Synthesis, Structural Diversity, Bioactivities and Mechanisms\nMini-Reviews in Medicinal Chemistry Signaling Pathways Regulating Gliomagenesis\nCurrent Molecular Medicine Endocannabinoids and Their Receptors: Physiology, Pathology and Pharmacology\nImmunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases\nCurrent Genomics Automated Brain Tumor Detection using Ideal Shallow Neural Network with Artificial Jellyfish Optimization\nCurrent Medical Imaging An Orally Bioavailable c-Met Kinase Inhibitor Potently Inhibits Brain Tumor Malignancy and Growth\nAnti-Cancer Agents in Medicinal Chemistry Metallothioneins and Platinum(II) Anti-Tumor Compounds\nCurrent Medicinal Chemistry Accuracy of Magnetic Resonance Spectroscopy in Discrimination of Neoplastic and Non-Neoplastic Brain Lesions\nCurrent Medical Imaging Expression and Function of Angiomodulating Cytokines in Rheumatoid Arthritis and Experimental Arthritis: Important Therapeutic Targets\nCurrent Immunology Reviews (Discontinued) Anti-Angiogenic Therapy as a Cancer Treatment Paradigm\nCurrent Medicinal Chemistry - Anti-Cancer Agents","source_license":"CC0","license_restricted":false}