Identification and characterisation of human endometrial stem/progenitor cells

Caroline E. Gargett
In: Australian and New Zealand Journal of Obstetrics and Gynaecology · 2006 · vol. 46(3) , pp. 250–253 · doi:10.1111/j.1479-828x.2006.00582.x · PMID:16704483 · W2000321193
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Researchers identified rare clonogenic epithelial and stromal cells in human endometrium, likely representing stem/progenitor populations, by initiating large clones.

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Abstract

The human endometrium is a dynamic, cyclically regenerating tissue. Because adult stem cells are present in other regenerative tissues, a clonal analysis of purified endometrial epithelial and stromal cells derived from hysterectomy tissue was undertaken, as a first attempt to identify and characterise endometrial stem/progenitor cells. Rare populations of epithelial and stromal cells were clonogenic. Only those cells initiating large clones, 0.09% of epithelial cells and 0.02% of stromal cells, are likely to be endometrial stem/progenitor cells.

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