Current understanding of endometrial stem cells

Irene Cervelló Alcaraz, Claudia Gil-Sanchís, Aymara Mas Perucho, Carlos Simón
In: Expert Review of Obstetrics & Gynecology · 2009 · vol. 4(3) , pp. 273–282 · doi:10.1586/eog.09.12 · W2164692268
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Endometrial stem cells, defined by functional properties due to lacking specific markers, are present in human and murine endometria and are presumed to have a mesenchymal origin, though further research is needed to understand their role in gynecological disorders.

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Abstract

Somatic stem cells (SSCs) are defined as a rare population of undifferentiated cells residing in differentiated tissues and organs. Different studies and diverse approaches suggest the presence of SSCs in human and murine endometria. Owing to the lack of specific phenotypic markers to identify endometrial SSCs, they are defined by their functional properties. The embryological origin of the uterus and the putative implication of bone marrow in endometrial regeneration suggest their presumed mesenchymal origin. Nevertheless, more information is needed regarding the physiology of endometrial stem cells to understand the gynecological disorders associated with abnormal endometrial proliferation, such as endometriosis and endometrial cancer.

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endometriosis

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